169045-01-6

Basic information

• Product Name: 7-AMINO-4-BROMOISOINDOLIN-1-ONE
• Synonyms: 7-AMINO-4-BROMOISOINDOLIN-1-ONE;7-Amino-4-bromo-2,3-dihydro-isoindol-1-one
• CAS NO: 169045-01-6
• Molecular Formula: C₈H₇BrN₂O
• Molecular Weight: 227.06
• Mol File: 169045-01-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 524.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.753±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly, Sonicated), Tetrahydrofuran (Very Slightly)
• PKA: 13.56±0.20(Predicted)
• CAS DataBase Reference: 7-AMINO-4-BROMOISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-AMINO-4-BROMOISOINDOLIN-1-ONE(169045-01-6)
• EPA Substance Registry System: 7-AMINO-4-BROMOISOINDOLIN-1-ONE(169045-01-6)

Safety Data

• Hazardous Substances Data: 169045-01-6(Hazardous Substances Data)

Usage

General Description

7-Amino-4-bromoisoindolin-1-one is a chemical compound with the molecular formula C8H6BrNO2. It is an organic compound with a yellow-brown solid appearance. 7-AMINO-4-BROMOISOINDOLIN-1-ONE is used in the synthesis of pharmaceuticals and other organic compounds, and it is known for its potential as a building block in organic chemistry. It has been researched for its potential use in the development of new drugs and as a reagent in chemical processes. Additionally, it is known for its unique structure and properties that make it an important compound in organic and medicinal chemistry research.

Upstream product

• 866767-06-8 4-amino-7-bromoisoindoline-1,3-dione 
• 2518-24-3 3-aminophthalimide 
• 866767-11-5 7-amino-4-bromo-3-hydroxyisoindolinone 
• 169044-98-8 7-amino-2,3-dihydro-1H-isoindol-1-one 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 765948-99-0 4-bromo-7-nitroisoindolin-1-one 
• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 

Downstream Products

• 913390-22-4 7-amino-4-(4-hydroxy-3-methoxyphenyl)isoindolinone 

Relevant articles and documents

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show select

HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF

The present invention relates to a class of isoindolinone derivatives and use thereof in the preparation of a medicament for treating diseases associated with a novel colony stimulating factor 1 receptor (CSF-1R) inhibitor. In particular, the present invention relates to a compound of formula (I) and a pharmaceutically acceptable salt thereof or a stereoisomer thereof.

JAK INHIBITOR

A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.