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16907-09-8

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16907-09-8 Usage

General Description

1-(4-Methoxyphenyl)-1H-pyrazol-5-amine is a chemical compound with the molecular formula C10H11N3O. It is an organic compound that belongs to the class of pyrazole derivatives. 1-(4-Methoxyphenyl)-1H-pyrazol-5-amine is a derivative of pyrazole and contains a 4-methoxyphenyl group attached to the pyrazole ring. It is commonly used in the pharmaceutical and chemical industries for the synthesis of various drugs and organic compounds. This chemical may have potential biological and pharmacological activities, and further research is being conducted to explore its potential applications.

Check Digit Verification of cas no

The CAS Registry Mumber 16907-09-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,9,0 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16907-09:
(7*1)+(6*6)+(5*9)+(4*0)+(3*7)+(2*0)+(1*9)=118
118 % 10 = 8
So 16907-09-8 is a valid CAS Registry Number.

16907-09-8Relevant articles and documents

The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition

Chen, Hui,Wang, Bin,Li, Peng,Yan, Hong,Li, Gang,Huang, Haihong,Lu, Yu

, (2021/03/26)

In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent sulfaphenazole for the treatment of Mycobacterium tuberculosis (M. tuberculosis). Preliminary results indicate that the 4-aminobenzenesulfonamide moiety plays a key role in maintaining antimycobacterial activity. Compounds 10c, 10d, 10f and 10i through the optimization on phenyl ring at the R2 site on the pyrazole displayed promising antimycobacterial activity paired with low cytotoxicity. In particular, compound 10d displayed good activity (MIC = 5.69 μg/mL) with low inhibition of CYP 2C9 (IC50 > 10 μM), consequently low potential risk of drug-drug interaction. These promising results provide new insight into the combination regimen using sulfonamide as one component for the treatment of M. tuberculosis.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

-

, (2013/02/28)

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine alpha7 receptor.

PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS

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Page/Page column 50, (2011/10/13)

Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.

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