169169-33-9

Upstream product

• 1885-14-9 phenyl chloroformate 
• 58761-14-1 4-(2,2,3,3-tetrafluoropropoxy)aniline 
• 109230-72-0 4-(2,2,3,3-tetrafluoropropoxy)nitrobenzene 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 169169-35-1 1-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone 
• 1027144-67-7 C₁₀H₁₁F₄N₃O₂ 

Relevant academic research and scientific papers

Injectable composition and a method of producing the same

An injectable oil-in-water emulsion composition comprises an antifungal triazole compound of the following formula (I) STR1 wherein Ar represents a substituted phenyl group; R1 and R2 represent, independently, a hydrogen atom or a lo

Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

A new series of optically active antifungal azoles, N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones (1,2) and 5(1H,4H)-tetrazolones (3), were prepared from the triflate derivative of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (13) by an SN2 displacement reaction with the union of an azolone (17-19) and subsequent ring-opening reaction with 1H-1,2,4-triazole. The optically active oxiranylethanol 13 was synthesized from methyl (R)-lactate in a stereocontrolled manner. The azolones 1-3 prepared showed potent antifungal activities in vitro and in vivo.