169228-67-5Relevant academic research and scientific papers
Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals
Cannalire, Rolando,Amato, Jussara,Summa, Vincenzo,Novellino, Ettore,Tron, Gian Cesare,Giustiniano, Mariateresa
, p. 14077 - 14086 (2020/11/20)
A new visible light-induced photocatalytic protocol enabling the formation of secondary amides from electron-poor organic bromides and isocyanides was developed. In addition, the in situ interception of ketenimine intermediates with nitrogen nucleophiles such as amines, hydrazines, and TMSN3 afforded, in a one-pot two-step procedure, valuable scaffolds such as ketene aminals, pyrazolones, and tetrazoles. Mechanistic evidence confirmed a radical pathway where isocyanides acted as radical geminal acceptors generating key imidoyl radical species.
Palladium-catalyzed selective hydrogenolysis of N-alkyl(aryl)-substituted γ-keto amides as an approach to γ-lactams or linear amides
Turova,Berezhnaya,Starodubtseva,Vinogradov
, p. 1065 - 1068 (2016/02/09)
A palladium-catalyzed hydrogenolysis of N-substituted γ-keto amides can proceed with participation of tautomeric 5-hydroxypyrrolidin-2-ones and give either pyrrolidin-2-ones, or linear amides, or their mixtures, depending on the substrate structure.
Preparation of 3-Hydroxyindolin-1-ones and o-Acylbenzamides. A Study of Ring-Chain Tautomerism
Nishio, Takehiko,Yamamoto, Hiroshi
, p. 883 - 892 (2007/10/02)
3-Hydroxyisoindolinones (ring form) as well as their chain tautomers, o-acylbenzamides, were prepared from the reactions of 3-benzalphthalide 1, 3-halophthalides 3, and o-acylbenzoic acids 6 or their esters 7 with amines 2, and those of phthalimides 4 wit
