169270-80-8Relevant articles and documents
Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzocycloheptene and Dibenzooxepin Derivatives. Searching for Bioisosteres of Biphenylyltetrazole Using a Three-Dimensional Search Technique
Kiyama, Ryuichi,Honma, Tsunetoshi,Hayashi, Kunio,Ogawa, Masayoshi,Hara, Mariko,et al.
, p. 2728 - 2741 (2007/10/03)
Three-dimensional substructure searching (3D search), using the program MACCS-3D, was utilized for designing novel angiotensin II receptor antagonists which contain a bioisostere of the biphenylyltetrazole moiety of DuP 753.A 3D query was prepared from an