169286-84-4Relevant academic research and scientific papers
TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
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Page/Page column 47, (2009/12/23)
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3- diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.
TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS
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Page/Page column 144, (2010/11/26)
Triazole derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme
Raddatz, Rita,Savic, Sandra L.,Bakthavachalam, Venkatesalu,Lesnick, John,Jasper, Jeffrey R.,McGrath, Christopher R.,Parini, Angelo,Lanier, Stephen M.
, p. 1135 - 1145 (2007/10/03)
A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B-and its role in substrate processing. The rank order o
