169286-84-4Relevant articles and documents
TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
-
Page/Page column 47, (2009/12/23)
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3- diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.
Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme
Raddatz, Rita,Savic, Sandra L.,Bakthavachalam, Venkatesalu,Lesnick, John,Jasper, Jeffrey R.,McGrath, Christopher R.,Parini, Angelo,Lanier, Stephen M.
, p. 1135 - 1145 (2007/10/03)
A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B-and its role in substrate processing. The rank order o