169298-35-5

Basic information

• Product Name: 4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol
• Synonyms: 4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol
• CAS NO: 169298-35-5
• Molecular Weight: 361.846
• Mol File: 169298-35-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol(169298-35-5)
• EPA Substance Registry System: 4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol(169298-35-5)

Safety Data

• Hazardous Substances Data: 169298-35-5(Hazardous Substances Data)

Upstream product

• 151389-59-2 2-(4-chlorobenzenesulfonylamino)ethyl bromide 
• 1025925-13-6 3-fluoro-4-hydroxythiophenol 
• 1026456-51-8 3-Fluoro-4-hydroxy-benzenesulfonyl chloride 
• 367-12-4 2-fluorophenol 

Downstream Products

• 151389-51-4 methyl 2-bromo-4-<2-(4-chlorophenylsulfonylamino)ethylthio>-6-fluorophenoxyacetate 
• 169298-36-6 2-bromo-4-<2-(4-chlorophenylsulfonylamino)ethylthio>-2-fluorophenol 

Relevant articles and documents

Synthesis and evaluation of novel fluorinated sulotroban-related sulfonamide derivatives as thromboxane A2 receptor antagonists

A series of sulotroban-related arylsulfonamide derivatives possessing a fluorinated phenoxyacetic acid moiety was synthesized and tested for TXA2 antagonizing ability on U-46619-induced platelet aggregation of rabbit platelet-rich plasma. Introduction of one or more fluorine atoms to the phenoxyacetic acid moiety increased this activity. The most potent compound among these compounds was 10c, which was 40-fold more potent (IC50 3.4 x 10-7 M) than sulotroban. 10c exhibited high activity (ID50 0.14 mg/kg) against a D-46619-induced acute thrombocytopenia model in mice when orally administrated. These findings and those of radioligand binding assays with various ligands showed 10c to be a potent and selective systemic TXA2 receptor antagonist.