169328-87-4

Usage

Uses

Used in Organic Synthesis:
Thiophene, 2-bromo-3,4-dimethylis utilized as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for further functionalization and modification, enabling the synthesis of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Thiophene, 2-bromo-3,4-dimethylserves as a building block for the development of new drugs. Its specific chemical properties make it a valuable component in the synthesis of potential therapeutic agents, contributing to drug discovery and development efforts.
Used in Agrochemical Industry:
Thiophene, 2-bromo-3,4-dimethylis also employed in the agrochemical industry as a precursor for the synthesis of various agrochemicals. Its unique structure and properties can be leveraged to create compounds with specific pesticidal or herbicidal activities, enhancing crop protection and yield.
Used in Materials Science:
In the field of materials science, Thiophene, 2-bromo-3,4-dimethylcan be used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with tailored characteristics, such as improved conductivity, stability, or other desirable properties.
It is important to handle Thiophene, 2-bromo-3,4-dimethylwith care and in compliance with safety regulations, as it may pose health and environmental risks. Proper handling and disposal practices should be followed to minimize potential hazards associated with this chemical compound.

Upstream product

• 632-15-5 3,4-dimethylthiophene 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 1795-04-6 2,3,4-trimethylthiophene 

Relevant academic research and scientific papers

In vivo phenotypic drug discovery: Applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a desirable pharmacology. This capability is particularly important when studying CNS diseases where drug efficacy may require modulation of multiple targets in order to overcome a robust, adaptive biological system. Here, we report the application of a mouse-based high-dimensional behavioral assay to the discovery and optimization of a structurally and mechanistically novel antipsychotic. Lead optimization focused on optimizing complex behavioral features and no explicit effort was made to identify the target (or targets) involved.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

IMIDAZOPYRIDAZINE COMPOUNDS

The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

Porphyrin compositions

Novel metal porphyrin compositions useful as organic phosphors are provided. The novel compositions are prepared from commercially available porphyrin-containing starting materials. In one instance a novel palladium-containing porphyrin composition having a number average molecular weight of greater than 12,000 grams per mole was prepared from 5,10,15,20-tetrakis(3′,5′-di(hydroxy)phenyl)-21H-23H-porphyrin by reaction first with palladium(II) acetylacetonate, followed by reaction with 2-bromo-2-methylpropionyl bromide, and subsequent group transfer reaction of the alpha-bromo ester groups with 9,9-dioctyl-2-vinylfluorene in the presence of CuBr as a radical initiator. The product polymer exhibited a number average molecular weight of 12,884 grams per mole, a weight average molecular weight of 14,338 grams per mole, and a robust red phosphorescent emission. Porphyrin containing copoylmers comprising structural units derived from 9,9-dioctyl-2-vinylfluorene and 9-anthracenylmethyl methacrylate were prepared in a similar fashion.

Side-chain Effects on the Fragmentation Behaviour of Alkylthiophenes

The processes leading to the fragment ions formed from alkylthiophene molecule ions by benzylic cleavage without and with transfer of one hydrogen from the side-chain to the ring and the influence of additional methyl groups on the relative importance of these two fragmentation reactions were investigated.