1795-04-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2,3,5-Trimethylthiophene is utilized as a key building block in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used in Fragrance and Flavoring Industry:
2,3,5-TRIMETHYLTHIOPHENE is employed as a fragrance ingredient and flavoring agent, enhancing the sensory properties of various consumer products due to its strong, sweet aroma.
Used in Polymer Manufacturing:
2,3,5-Trimethylthiophene serves as a valuable component in the production of polymers, contributing to the creation of materials with specific properties for diverse applications.
Used as a Chemical Intermediate in Organic Synthesis:
2,3,5-TRIMETHYLTHIOPHENE is also used as a chemical intermediate, playing a crucial role in the synthesis of other organic compounds for various industrial applications.
It is important to handle and store 2,3,5-Trimethylthiophene with care due to its potential health and environmental risks if mismanaged.

Upstream product

• 343268-79-1 3,4-dimethylthiophene-2-carbaldehyde 
• 14503-51-6 tetramethylthiophene 
• 188290-36-0 thiophene 
• 624-92-0 Dimethyldisulphide 
• 169328-87-4 2-bromo-3,4-dimethylthiophene 
• 74-88-4 methyl iodide 
• 3141-25-1 2,3,4-tribromothiophene 
• 632-15-5 3,4-dimethylthiophene 
• 3141-26-2 3,4-dibromothiophene 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1451066-43-5 trimethyl-2-(2,4,6-trimethylphenyl)thiophene 
• 188290-36-0 thiophene 
• 632-16-6 2,3-dimethylthiophene 
• 14503-51-6 tetramethylthiophene 

Relevant academic research and scientific papers

Synthesis and structure of novel disulfide(trisulfide)-containing thiophenes

A novel trisulfide-containing thiophene, 1,5-dihydrothieno[3,4-e][1,2,3] trithiepine (5), and a disulfide analogue, 1,4-dihydrothieno[3,4-d][1,2]dithiine (4), were designed and synthesized. All the compounds were characterized by FT-IR, NMR, Raman, MS, an

Catalytic Synthesis of Methylthiophenes

The gas-phase reaction of dimethyl disulfide with thiophene over Co/HZSM-5 catalyst in a helium medium under atmospheric pressure at 250–350°C gave a mixture of mono-, di-, tri-, and tetramethylthiophenes with an overall selectivity of 94–96%.

Reaction of dimethyl disulfide with thiophene catalyzed by zeolite

Reaction of dimethyl disulfide with thiophene under the action of highly siliceous zeolite at 180-350°C and contact time 0.6-14 s resulted in formation of thioalkylation products, 2-(methylsulfanyl)- and 2,5-bis(methylsulfanyl)thiophenes and also alkylate

Catalytic reactions of dimethyl disulfide with thiophene and benzene

The gas-phase reaction of dimethyl disulfide with thiophene proceeds under the action of acid catalysts under atmospheric pressure at 160-350°C and a residence time of τ = 0.6-21 s to form thioalkylation and alkylation products. Dimethyl disulfide reacts with benzene to form only alkylation products. Catalysts containing both strong protic and Lewis acid sites, as well as basic sites of moderate strength, are the most active ones.

In vivo phenotypic drug discovery: Applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a desirable pharmacology. This capability is particularly important when studying CNS diseases where drug efficacy may require modulation of multiple targets in order to overcome a robust, adaptive biological system. Here, we report the application of a mouse-based high-dimensional behavioral assay to the discovery and optimization of a structurally and mechanistically novel antipsychotic. Lead optimization focused on optimizing complex behavioral features and no explicit effort was made to identify the target (or targets) involved.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Equilibrium studies of thiophene exchange in (η-thiophene)Ru(η-C5H5)+: A model for thiophene adsorption on hydrodesulfurization catalysts

Equilibrium constants (K′) for the displacement of the π- (i.e., η5-) thiophene (T) ligand in CpRu(T)+ by methyl-substituted thiophenes (Th′), CpRu(T)+ + Th′ ? CpRu(Th′)+ + T, increase as the number of methyl groups in Th′ increases: T (1) 2T (35) 2T (50) 3T(200) 3T (300) 4T (1300). The K′ values increase by a factor of approximately 6 for each methyl in the thiophene (Th′). That thiophenes also adsorb to a Co-Mo/Al2O3 hydrodesulfurization (HDS) catalyst more strongly as the number of methyl groups in the thiophene increases suggests that they are also π-bonded to the catalyst surface. The results suggest that trends in rates of deuterium exchange and hydrodesulfurization on HDS catalysts for a series of methyl-substituted thiophenes are determined by their relative strengths of adsorption to the catalyst surface.

Polyene compounds

Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.