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(2-nitrophenyl)(pyrrolidin-1-yl)methanone, also known as NPPM, is a chemical compound with the molecular formula C12H13NO3. It is a yellow to orange powder that is commonly used as an intermediate in the synthesis of pharmaceutical compounds, agrochemicals, and other organic compounds. NPPM has been studied for its potential anti-inflammatory and anti-cancer properties. It is also used in the preparation of various heterocyclic compounds and as a building block in organic synthesis. NPPM should be handled with care, as it is a potentially hazardous chemical that may cause skin and eye irritation, and should only be used by trained professionals in a controlled laboratory setting.

169330-07-8

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169330-07-8 Usage

Uses

Used in Pharmaceutical Industry:
(2-nitrophenyl)(pyrrolidin-1-yl)methanone is used as an intermediate in the synthesis of pharmaceutical compounds for its potential anti-inflammatory and anti-cancer properties.
Used in Agrochemical Industry:
(2-nitrophenyl)(pyrrolidin-1-yl)methanone is used as an intermediate in the synthesis of agrochemicals for its potential applications in pest control and crop protection.
Used in Organic Synthesis:
(2-nitrophenyl)(pyrrolidin-1-yl)methanone is used as a building block in organic synthesis for the preparation of various heterocyclic compounds and other organic compounds.
Used in Research and Development:
(2-nitrophenyl)(pyrrolidin-1-yl)methanone is used in research and development for studying its potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 169330-07-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,3,3 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169330-07:
(8*1)+(7*6)+(6*9)+(5*3)+(4*3)+(3*0)+(2*0)+(1*7)=138
138 % 10 = 8
So 169330-07-8 is a valid CAS Registry Number.

169330-07-8Relevant academic research and scientific papers

Visible-Light-Mediated Oxidative Amidation of Aldehydes by Using Magnetic CdS Quantum Dots as a Photocatalyst

Xu, Ling,Zhang, Shuai-Zheng,Li, Wei,Zhang, Zhan-Hui

, p. 5483 - 5491 (2021)

A magnetic CdS quantum dot (Fe3O4/polydopamine (PDA)/CdS) was synthesized through a facile and convenient method from inexpensive starting materials. Characterization of the prepared catalyst was performed by means of FTIR spectrosco

Visible-Light-Driven C-N Bond Formation by a Hexanickel Cluster Substituted Polyoxometalate-Based Photocatalyst

Chang, Jiangnan,Han, Qiuxia,Jiao, Jiachen,Li, Jie,Li, Mingxue

, p. 10022 - 10029 (2021)

A powerful and attractive route to develop novel photocatalysts for C-N bond formation involves the use of pyrrolidine as the substrate and cocatalyst simultaneously. Herein, a new polyoxometalate (POM)-based metal-organic framework, namely, [Ni6(OH)3(H2O

METHODS OF CONTROLLING CROP PESTS USING AROMATIC AMIDE INSECT REPELLENTS, METHODS OF MAKING AROMATIC AMIDE INSECT REPELLENTS, AND NOVEL AROMATIC AMIDE INSECT REPELLENTS

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Paragraph 0068-0069, (2022/03/18)

Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal. The compounds have the formula RxC6Hy—C(═O)—N(Cy), where RxC6Hy is a substituted phenyl group, each R group is independently C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, C1-C4 alkoxy, C6-C10 aryloxy, halogen, nitro, cyano, cyanate, isocyanate, nitroso, C1-C4 alkylthio, phenylthio, (halogen-substituted) C1-C4 alkylsulfonyl, phenylsulfonyl, tolylsulfonyl, amino, mono- or di-C1-C4 alkylamino, diphenylamino, di-C1-C4 alkylamido, formyl, C2-C7 acyl, or C1-C6 alkoxycarbonyl; x is an integer of 1 to 5; x+y=5; Cy is a C2-C8 (substituted) alkadiyl, a C4-C6 (substituted) alkenediyl, or a (substituted) diyl of the formula —(CH2CH2)—O—(CH2CH2)—, —(CH2CH2)—NR′—(CH2CH2)— or —(CH2CH2)—S—(CH2CH2)— that, along with the amide N atom, forms a non-aromatic cyclic group; and R′ is C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, or (substituted) benzyl.

One-Pot Tandem Photoredox and Cross-Coupling Catalysis with a Single Palladium Carbodicarbene Complex

Hsu, Yu-Cheng,Wang, Vincent C.-C.,Au-Yeung, Ka-Chun,Tsai, Chung-Yu,Chang, Chun-Chi,Lin, Bo-Chao,Chan, Yi-Tsu,Hsu, Chao-Ping,Yap, Glenn P. A.,Jurca, Titel,Ong, Tiow-Gan

supporting information, p. 4622 - 4626 (2018/03/21)

The combination of conventional transition-metal-catalyzed coupling (2 e? process) and photoredox catalysis (1 e? process) has emerged as a powerful approach to catalyze difficult cross-coupling reactions under mild reaction conditions. Reported is a palladium carbodicarbene (CDC) complex that mediates both a Suzuki–Miyaura coupling and photoredox catalysis for C?N bond formation upon visible-light irradiation. These two catalytic pathways can be combined to promote both conventional transition-metal-catalyzed coupling and photoredox catalysis to mediate C?H arylation under ambient conditions with a single catalyst in an efficient one-pot process.

Supported cobalt oxide nanoparticles as efficient catalyst in esterification and amidation reactions

Rajabi, Fatemeh,Raessi, Mojdeh,Arancon, Rick A.D.,Saidi, Mohammad Reza,Luque, Rafael

, p. 122 - 126 (2015/01/09)

Co/SBA-15 nanoparticle catalysts (CoNP) were prepared using a commonly adapted synthetic route and then utilised for esterification and amidation reactions using aromatic and linear chain compounds for the production of long chain esters and amides. The study shows that the use of CoNP catalysts favours the use of aromatic reactants with electron donating substituents specifically in the para position. For the amidation reaction, good to excellent yields were obtained demonstrating tolerance towards differently substituted aromatic compounds. Overall, the synthesized catalysts proved to be efficient and highly versatile, and recyclable under the investigated conditions.

Phenazinium salt-catalyzed aerobic oxidative amidation of aromatic aldehydes

Leow, Dasheng

supporting information, p. 5812 - 5815 (2015/02/19)

Amides are prevalent in organic synthesis. Developing an efficient synthesis that avoids expensive oxidants and heating is highly desirable. Here the oxidative amidation of aromatic aldehydes is reported using an inexpensive metal-free visible light photocatalyst, phenazine ethosulfate, at low catalytic loading (1-2 mol %). The reaction proceeds at ambient temperature and uses air as the sole oxidant. The operationally easy procedure provides an economical, green, and mild alternative for the formation of amide bonds.

Metal-free one-pot oxidative amination of aldehydes to amides

Ekoue-Kovi, Kekeli,Wolf, Christian

, p. 3429 - 3432 (2008/02/12)

Metal-free oxidative amination of aromatic aldehydes in the presence of TBHP provides convenient access to amides in 85-99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.

Trapping of translocated radicals by tetrathiafulvalene radical cation

Murphy, John A.,Roome, Stephen J.

, p. 1349 - 1358 (2007/10/02)

Aryl radicals are generated by electron transfer from tetrathiafulvalene to arenediazonium salts.The aryl radicals are translocated into alkyl radicals which undergo a C-S or C-C bond formation to tetrathiafulvalene radical cation, depending on the nucleophilicity/electrophilicity of the translocated carbon radical.

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