169330-64-7

Upstream product

• 533-58-4 2-Iodophenol 
• 781-03-3 isopentenyl tosylate 
• 763-32-6 2-methyl-1-buten-4-ol 
• 10523-96-3 3-methyl-3-butenyl chloride 

Downstream Products

• 1204606-64-3 4-(4-methoxybenzyl)-4-methylchroman 
• 1204606-55-2 5-(4-methoxyphenyl)-4,4-dimethylchroman 

Relevant academic research and scientific papers

Palladium-Catalyzed Domino Reaction of Two Aryl Iodides involving C–H Activation Processes: Efficient Synthesis of Fused Polycycles

The palladium-catalyzed domino intermolecular C(sp2)–H activation reaction of two aryl iodides was explored. This simple palladium catalytic system showed good activity.

A Facile Construction of Bisheterocyclic Methane Scaffolds through Palladium-Catalyzed Domino Cyclization

A convenient palladium-catalyzed domino cyclization reaction for the construction of bis(benzofuranyl)methane scaffolds bearing an all-carbon quaternary center has been described. In the cascade process, one C(sp2)—O bond, two C(sp2)—C(sp3) bonds as well as two benzofuran rings are formed in a single synthetic sequence. The approach shows wide scope of substrates and good functional-group tolerance. Moreover, this methodology is successfully extended to the synthesis of benzofuranyl methyl chromane derivatives.

Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS

A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.

Palladium-catalyzed domino Mizoroki-Heck/intermolecular C(sp3)-H activation sequence: An approach to the formation of C(sp3)-C(sp3) bonds

A palladium-catalyzed domino Mizoroki-Heck/intermolecular unactivated C(sp3)-H alkylation reaction has been developed. This simple palladium nanoparticle catalytic system shows good activity and affords the dimeric dihydrobenzofuran derivatives

Pd-Catalyzed Highly Regio- and Stereoselective Formation of C-C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes

A highly regio- and stereoselective C-C double bond formation reaction via Pd-catalyzed Heck-type cascade process with N-tosylhydrazones has been developed. Various N-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstituted olefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance and different benzofuran-, dihydrobenzofuran-, and indoline-containing alkene products were obtained with high selectivity.

Water-controlled regioselectivity of Pd-catalyzed domino reaction involving a C-H activation process: Rapid synthesis of diverse carbo- And heterocyclic skeletons

[Chemical equaction presented] palladium-catalyzed domino reaction Involving a C-H activation process to synthesize diverse carbo- and heterocyclic skeletons was developed. H2O (as cosolvent) is used to control the regioselectivlty.

Pd-catalyzed alkyl to aryl migration and cyclization: An efficient synthesis of fused polycycles via multiple C-H activation

A novel palladium migration methodology for the synthesis of complex fused polycycles has been developed. This process involves 1,4-palladium alkyl to aryl migrations via through-space C-H activation, followed by intramolecular arylation or an intermolecu