169437-81-4

Basic information

• Product Name: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene
• Synonyms: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene
• CAS NO: 169437-81-4
• Molecular Weight: 496.562
• Mol File: 169437-81-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene(CAS DataBase Reference)
• NIST Chemistry Reference: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene(169437-81-4)
• EPA Substance Registry System: trans-(7R,8R)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene(169437-81-4)

Upstream product

• 98-88-4 benzoyl chloride 
• 63268-36-0 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7R,8R)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester 
• 57405-00-2 (+/-)-7,8,9,10-Tetrahydrobenzopyrene-trans-7,8-diol dibenzoate 
• 36504-67-3 7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 17573-15-8 9,10-dihydro benzopyrene 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 60864-95-1 (-)-7R-trans-Benzopyrene-7,8-dihydrodiol 
• 63323-31-9 (-)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene 
• 63268-38-2 7,8-bis-benzoyloxy-7,8-dihydro benzo[a]pyrene 

Relevant articles and documents

Enantioselective Synthesis of the (+)-anti-7,8-Dihydrodiol-9,10-epoxide of the Potent Carcinogen Benzopyrene

The title compound, the most important genotoxic metabolite of benzopyrene, has been prepared efficiently in a synthesis which capitalized on Jacobsen-type enantioselective epoxidation of 9,10-dihydrodibenzopyrene, cleavage of the epoxide by KOH-Me2SO to give the tetrahydro-trans-7,8-diol, and formation of the dibenzoate from which the contaminating antipode was removed by crystallization.