169448-87-7

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-N-Boc-2-(hydroxymethyl)piperazine is used as a key intermediate in the synthesis of novel substituted quinoline-8-carbonitrile derivatives. These derivatives possess androgen receptor degradation activity, which makes them potential candidates for the development of new drugs targeting androgen receptor-related diseases, such as prostate cancer and other androgen-dependent conditions.
In the field of medicinal chemistry, (R)-1-N-Boc-2-(hydroxymethyl)piperazine serves as a versatile starting material for the creation of new therapeutic agents. Its unique structure allows for further functionalization and modification, enabling the development of molecules with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Additionally, (R)-1-N-Boc-2-(hydroxymethyl)piperazine may find applications in other industries, such as agrochemicals or materials science, where its specific structural features and reactivity can be exploited for the development of new products with desired properties. However, the primary focus of its use remains in the pharmaceutical industry, where its potential for contributing to the development of innovative therapeutics is most significant.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-6-8(12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 149715-46-8 (R)-4-(phenylmethyl)-2-piperazinemethanol 
• 930782-89-1 (R)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 
• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 
• 1257855-72-3 (R)-tert-butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate 
• 149648-97-5 (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione 
• 366003-57-8 (+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate 

Downstream Products

• 1442445-45-5 (S)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1442445-58-0 (S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1401729-14-3 C₃₀H₄₁N₅O₃ 
• 1220229-48-0 tert-butyl-(2R)-4-((6-bromo-1-oxo-2-(phenylsulfonyI)-1,2-dihydroisoquinolin-4-yl)methyl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1070294-93-7 (R)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((3-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide 

Relevant academic research and scientific papers

Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)

The invention belongs to the field of pharmaceutical chemistry, and relates to a fluorine-substituted monocarbazole derivative which is one or more of compounds represented by formula (I) and formula (II) or a pharmaceutically acceptable soluble salt formed by a compound represented by formula (II). The fluorine-substituted monocarbazole derivatives obtained in the application can be used for preparing DNA methyltransferase inhibitors or histone demethylase inhibitors. The fluorine-substituted monocarbazole derivative has an inhibitory effect on the proliferation of cancer cells and can be used for preparing medicaments for treating and/or preventing cancer. An in-vitro cancer cell proliferation inhibition test shows that the fluorine-substituted monocarbazole compound obtained by the invention shows anti-proliferation activity against human lung cancer cells (A549), human colon cancer cells (HCTCTCT116), human gastric cancer cells (MNK NK NK-45), human liver cancer cells (HepepepG2), RPMI PMI PMI PMI PMI PMI and Karpppp289. (by machine translation)

Fluorine-substituted bimolecular carbazole derivative as well as preparation method and application thereof

The invention discloses a fluorine-substituted bimolecular carbazole derivative represented by a formula (I) or pharmaceutically acceptable salt thereof. R1, R2, R3, R4 and R5 are defined in the specification. The fluorine-substituted bimolecular carbazole derivative or the pharmaceutically acceptable salt thereof provided by the invention can be used for preparing a DNA methyltransferase inhibitor or a histone demethylase inhibitor, and in-vitro cancer cell anti-proliferation tests prove that the fluorine-substituted bimolecular carbazole derivative has anti-proliferation activity on cancer cells.

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

A quinazoline derivative of the formula (I): (A chemical formula should be inserted here - please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.