169448-87-7

Basic information

• Product Name: (R)-1-N-Boc-2-(hydroxymethyl)piperazine
• Synonyms: (R)-1-Boc-2-Hydroxymethyl-piperazine;(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate;(R)-1-Boc-2-Hydroxymethyl-piperazine ,98%;(S)-1-Boc-2-Hydroxymethyl-piperazine ,98%;tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate;(R)-1-Boc-2-(hyroxyMethyl)piperazine;1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-;tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate
• CAS NO: 169448-87-7
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.2774
• Product Categories: Piperaizine
• Mol File: 169448-87-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.7 °C
• Appearance: /
• Density: 1.085 g/cm³
• Vapor Pressure: 1.98E-05mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: (R)-1-N-Boc-2-(hydroxymethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-N-Boc-2-(hydroxymethyl)piperazine(169448-87-7)
• EPA Substance Registry System: (R)-1-N-Boc-2-(hydroxymethyl)piperazine(169448-87-7)

Safety Data

• Hazardous Substances Data: 169448-87-7(Hazardous Substances Data)

Usage

Uses

(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-6-8(12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 149715-46-8 (R)-4-(phenylmethyl)-2-piperazinemethanol 
• 1257855-72-3 (R)-tert-butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate 
• 149648-97-5 (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione 
• 366003-57-8 (+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate 
• 930782-89-1 (R)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 
• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 

Downstream Products

• 1401729-14-3 C₃₀H₄₁N₅O₃ 
• 1442445-58-0 (S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1442445-45-5 (S)-tert-butyl 4-(3-((R)-1-(2,4-dichlorophenyl)ethylamino)-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1220229-48-0 tert-butyl-(2R)-4-((6-bromo-1-oxo-2-(phenylsulfonyI)-1,2-dihydroisoquinolin-4-yl)methyl)-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1070294-93-7 (R)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((3-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide 

Relevant articles and documents

Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)

The invention belongs to the field of pharmaceutical chemistry, and relates to a fluorine-substituted monocarbazole derivative which is one or more of compounds represented by formula (I) and formula (II) or a pharmaceutically acceptable soluble salt formed by a compound represented by formula (II). The fluorine-substituted monocarbazole derivatives obtained in the application can be used for preparing DNA methyltransferase inhibitors or histone demethylase inhibitors. The fluorine-substituted monocarbazole derivative has an inhibitory effect on the proliferation of cancer cells and can be used for preparing medicaments for treating and/or preventing cancer. An in-vitro cancer cell proliferation inhibition test shows that the fluorine-substituted monocarbazole compound obtained by the invention shows anti-proliferation activity against human lung cancer cells (A549), human colon cancer cells (HCTCTCT116), human gastric cancer cells (MNK NK NK-45), human liver cancer cells (HepepepG2), RPMI PMI PMI PMI PMI PMI and Karpppp289. (by machine translation)

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.