149648-97-5

Upstream product

• 76315-01-0 N-benzyl-N-(tert-butoxycarbonyl)glycine 
• 100-46-9 benzylamine 
• 366003-57-8 (+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate 
• 149648-96-4 N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester 

Downstream Products

• 149715-45-7 (S)-4-(phenylmethyl)-2-piperazinemethanol 
• 1257855-72-3 (S)-tert-butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate 
• 1030377-21-9 (S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 169448-87-7 (R)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1257855-72-3 (R)-tert-butyl4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate 
• 149648-99-7 (R)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate 
• 149648-98-6 (R)-methyl 3-(hydroxymethyl)-1-piperazinecarboxylate 
• 149715-47-9 (R)-piperazin-2-ylmethanol 
• 149715-46-8 (R)-4-(phenylmethyl)-2-piperazinemethanol 

Relevant academic research and scientific papers

Fluorine-substituted bimolecular carbazole derivative as well as preparation method and application thereof

The invention discloses a fluorine-substituted bimolecular carbazole derivative represented by a formula (I) or pharmaceutically acceptable salt thereof. R1, R2, R3, R4 and R5 are defined in the specification. The fluorine-substituted bimolecular carbazole derivative or the pharmaceutically acceptable salt thereof provided by the invention can be used for preparing a DNA methyltransferase inhibitor or a histone demethylase inhibitor, and in-vitro cancer cell anti-proliferation tests prove that the fluorine-substituted bimolecular carbazole derivative has anti-proliferation activity on cancer cells.

Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)

The invention belongs to the field of pharmaceutical chemistry, and relates to a fluorine-substituted monocarbazole derivative which is one or more of compounds represented by formula (I) and formula (II) or a pharmaceutically acceptable soluble salt formed by a compound represented by formula (II). The fluorine-substituted monocarbazole derivatives obtained in the application can be used for preparing DNA methyltransferase inhibitors or histone demethylase inhibitors. The fluorine-substituted monocarbazole derivative has an inhibitory effect on the proliferation of cancer cells and can be used for preparing medicaments for treating and/or preventing cancer. An in-vitro cancer cell proliferation inhibition test shows that the fluorine-substituted monocarbazole compound obtained by the invention shows anti-proliferation activity against human lung cancer cells (A549), human colon cancer cells (HCTCTCT116), human gastric cancer cells (MNK NK NK-45), human liver cancer cells (HepepepG2), RPMI PMI PMI PMI PMI PMI and Karpppp289. (by machine translation)

Carbostyril carboxylic compounds and intermediates, preparation method and application thereof

The invention discloses carbostyril carboxylic compounds and hydrochlorides thereof and also discloses a preparation method of the compounds and the hydrochlorides thereof as well as an application of the compounds and the hydrochlorides thereof in preparing gram-positive bacterium-preventing or gram-negative bacterium-preventing drugs. Moreover, the invention discloses intermediates for preparing the compounds and a preparation method of the intermediates.

A potent new class of κ-receptor agonist: 4-Substituted 1-(arylacetyl)- 2-[(dialkylamino)methyl]piperazines

The synthesis of 4-substituted 1-(arylacetyl)-2- [(alkylamino)methyl]piperazines (10-22, 26, 27, and 30-33) and their activities as κ-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter ser