1257855-72-3

Basic information

• Product Name: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
• Synonyms: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine;(2R)-2-(Hydroxymethyl)-4-(phenylmethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
• CAS NO: 1257855-72-3
• Molecular Formula: C17H26N2O3
• Molecular Weight: 306.39994
• Mol File: 1257855-72-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine(1257855-72-3)
• EPA Substance Registry System: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine(1257855-72-3)

Safety Data

• Hazardous Substances Data: 1257855-72-3(Hazardous Substances Data)

Usage

General Description

"(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine" is a chemical compound with a molecular formula C18H27N3O3. It is a piperazine derivative with a benzyl and a hydroxymethyl group attached to the piperazine ring. The compound is chiral, with the (R)-enantiomer being the active form. It is commonly used as an intermediate in organic synthesis for the production of pharmaceuticals and agrochemicals. The Boc (tert-butoxycarbonyl) group is a protecting group for amines, ensuring that the amine functionality remains unreactive under most reaction conditions. Additionally, the benzyl group provides stability to the molecule. The hydroxymethyl group adds a hydrophilic character to the molecule, making it useful in drug design and synthesis. (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine has potential applications in medicinal chemistry and drug development due to its structural features.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 85817-34-1 4-(phenylmethyl)-2-piperazinemethanol 
• 100-46-9 benzylamine 
• 149715-46-8 (R)-4-(phenylmethyl)-2-piperazinemethanol 
• 149648-97-5 (S)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione 
• 366003-57-8 (+)-(2S)-methyl 2-(2-chloroacetylamino)-3-hydroxypropanoate 
• 1030377-21-9 (S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 100-52-7 benzaldehyde 
• 149715-45-7 (S)-4-(phenylmethyl)-2-piperazinemethanol 
• 50-00-0 formaldehyd 
• 57260-70-5 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1214196-85-6 1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 100-39-0 benzyl bromide 
• 1214057-04-1 4-benzyl-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 

Downstream Products

• 85817-34-1 4-(phenylmethyl)-2-piperazinemethanol 
• 1380336-22-0 N¹-(((R)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine 
• 1380336-23-1 N¹-(((S)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine 
• 1030377-21-9 (S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 930783-25-8 (S)-hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one 
• 169448-87-7 (R)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Fluorine-substituted bimolecular carbazole derivative as well as preparation method and application thereof

The invention discloses a fluorine-substituted bimolecular carbazole derivative represented by a formula (I) or pharmaceutically acceptable salt thereof. R1, R2, R3, R4 and R5 are defined in the specification. The fluorine-substituted bimolecular carbazole derivative or the pharmaceutically acceptable salt thereof provided by the invention can be used for preparing a DNA methyltransferase inhibitor or a histone demethylase inhibitor, and in-vitro cancer cell anti-proliferation tests prove that the fluorine-substituted bimolecular carbazole derivative has anti-proliferation activity on cancer cells.

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (I), or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

General Procedures for the Lithiation/Trapping of N-Boc Piperazines

To provide α-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic approach is required. Here, we report the development of two general and simple procedures for the racemic lithiation/trapping of N-Boc piperazin