80354-46-7

Usage

Chemical structure

A synthetic chemical compound with a 2,4,5-trichlorophenyl group attached to a (2-chloroethyl)carbamate group.

Common uses

Antimicrobial agent in personal care products such as soaps, detergents, and body washes.

Mechanism of action

Inhibits the growth of bacteria on the skin, promoting hygiene and cleanliness.

Environmental impacts

Environmental contamination due to its persistence and bioaccumulation in water and soil.

Antibiotic resistance

Contributes to the development of antibiotic-resistant bacteria, posing a threat to public health.

Regulation status

Banned in some countries due to its potential health and environmental risks.

Need for further research

To better understand the long-term effects of triclocarban on human health and the environment, and to inform future regulations.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 95-95-4 2,4,5-trichlorophenol 
• 16947-69-6 2,4,5-Trichlorophenyl chloroformate 
• 870-24-6 2-chloroethanamine hydrochloride 

Downstream Products

• 80354-51-4 N-(chloro-2 ethyl)N-nitrosocarbamate de trichloro-2,4,5 phenyle 

Relevant academic research and scientific papers

Synthesis and preliminary in vitro evaluation of antitumor nitrosoureido cholesterol derivatives

A new class of chloroethyl nitrosourea analogues of cholesterol has been synthetized from the corresponding 7-amino and 7-aminoalkylcholesterol derivatives. Compounds III-V inhibited L1210 cell growth in culture much more effectively than N,N'-bis(2-cgloroethyl)-N'-nitrosourea (BCNU) after 48 h incubation. Stability and cytotoxic activity of these prodrugs are promising for brain tumor treatments and as lymphotropic vectors for tumor cells spreading along the lymphatic pathways.

Novel procedure for the preparation of activated nitrosocarbamates

The subject of the invention is a novel procedure for the preparation of the compounds of formula I: STR1 in which n varies in particular from 2 to 5 and R represents Cl, Br or F Z represents in particular hydrogen, characterized in that the halogenoformate of formula II: STR2 R and n having the meanings indicated above, Y representing a halogen, is made to react with NH2 CH2 CH2 Cl to form the compound of formula Ia: STR3 in which R has the meanings indicated above, and in that the compound Ia is treated directly with nitrosylsulfuric acid.

Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.