16948-36-0

Basic information

• Product Name: H-D-Glu(Otbu)-OMe.HCL
• Synonyms: D-glutamic acid γ-tert·butylester α-methyl este;D-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride;(R)-5-tert-Butyl 1-methyl 2-aminopentanedioate hydrochloride;5-O-tert-butyl 1-O-methyl (2R)-2-aminopentanedioate
• CAS NO: 16948-36-0
• Molecular Formula: C10H19NO4.ClH
• Molecular Weight: 253.724
• Mol File: 16948-36-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-D-Glu(Otbu)-OMe.HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Glu(Otbu)-OMe.HCL(16948-36-0)
• EPA Substance Registry System: H-D-Glu(Otbu)-OMe.HCL(16948-36-0)

Safety Data

• Hazardous Substances Data: 16948-36-0(Hazardous Substances Data)

Usage

General Description

H-D-Glu(Otbu)-OMe.HCl, also known as (2S)-2-[(tert-Butoxycarbonyl)amino]-4-methoxy-4-oxobutanoic acid hydrochloride, is a chemical compound with molecular formula C10H17NO6.HCl. It is used in scientific experimentation, specifically in peptide synthesis due to its ability of integrating with other compounds efficiently, without inducing a chemical reaction. Its chemical structure includes a tert-butyl (t-butoxycarbonyl) protective group, often used in peptide synthesis to protect amino groups. As a hydrochloride salt, it is likely to be stable and easily dissolved in water. However, like many chemicals, it should be handled with care as it may pose health risks if improperly used.

Upstream product

• 13726-84-6 Boc-Glu(OtBu)-OH 
• 18635-51-3 5-(tert-butyl) 1-methyl (tert-butoxycarbonyl)-L-glutamate 

Downstream Products

• 38155-01-0 Z-Lys(Boc)-Glu(OtBu)-OMe 
• 35793-59-0 tert-butyl methyl (S,S)-2-(4-((tert-butyl)oxycarbonyl)-2-((phenylmethoxy)carbonylamino) butanoylamino)pentane-1,5-dioate 
• 35793-61-4 (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 140707-01-3 (2S)-N-benzyloxycarbonyl-N-methylglutamic acid α-methyl ester γ-t-butyl ester 
• 150857-81-1 1-methyl N-acetyl-L-glutamic acid 
• 4902-24-3 methyl ((benzyloxy)carbonyl)-L-valyl-L-(O-tert-butyl)glutamate 
• 73793-91-6 N-Hexadecanoyl-L-glutamic acid α-methyl ester 
• 79640-68-9 α-methyl γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-glutamate 
• 95485-10-2 (S)-2-{4-[(4-Amino-2-formimidoylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 95485-11-3 (S)-2-{4-[(2-Amino-4-formimidoylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester 

Relevant articles and documents

Kinetic Selection in the Out-of-Equilibrium Autocatalytic Reaction Networks that Produce Macrocyclic Peptides

Autocatalytic reaction networks are instrumental for validating scenarios for the emergence of life on Earth and for synthesizing life de novo. Here, we demonstrate that dimeric thioesters of tripeptides with the general structure (Cys-Xxx-Gly-SEt)2 form strongly interconnected autocatalytic reaction networks that predominantly generate macrocyclic peptides up to 69 amino acids long. Some macrocycles of 6–12 amino acids were isolated from the product pool and were characterized by NMR spectroscopy and single-crystal X-ray analysis. We studied the autocatalytic formation of macrocycles in a flow reactor in the presence of acrylamide, whose conjugate addition to thiols served as a model “removal” reaction. These results indicate that even not template-assisted autocatalytic production combined with competing removal of molecular species in an open compartment could be a feasible route for selecting functional molecules during the pre-Darwinian stages of molecular evolution.