16948-38-2

Basic information

• Product Name: BOC-ILE-ONP
• Synonyms: BOC-ISOLEUCINE-ONP;BOC-ILE-ONP;BOC-L-ISOLEUCINE 4-NITROPHENYL ESTER;BOC-L-ISOLEUCINE P-NITROPHENYL ESTER;p-nitrophenyl erythro-N-(tert-butoxycarbonyl)-L-isoleucinate;N-tert-Butoxycarbonyl-L-isoleucine 4-nitrophenyl ester;Boc-L-Ile-ONp;N-alpha-t-Butyloxycarbonyl-L-isoleucine p-nitrophenyl ester
• CAS NO: 16948-38-2
• Molecular Formula: C₁₇H₂₄N₂O₆
• Molecular Weight: 352.38
• EINECS: 241-020-1
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 16948-38-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 487.8 °C at 760 mmHg
• Flash Point: 248.8 °C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 1.15E-09mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C
• PKA: 10.87±0.46(Predicted)
• BRN: 1894884
• CAS DataBase Reference: BOC-ILE-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-ILE-ONP(16948-38-2)
• EPA Substance Registry System: BOC-ILE-ONP(16948-38-2)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 16948-38-2(Hazardous Substances Data)

Usage

General Description

BOC-ILE-ONP is a chemical compound containing the amino acid isoleucine, with a BOC (tert-butyloxycarbonyl) protecting group and an ONP (o-nitrophenyl) ester. BOC-ILE-ONP is commonly used in peptide synthesis as a building block for creating larger peptide molecules. The BOC protecting group helps to protect the reactive amine group of the isoleucine, while the ONP ester group is used to facilitate the coupling of the isoleucine to other amino acids in the peptide synthesis process. BOC-ILE-ONP is an important reagent in the field of peptide chemistry, allowing for the creation of complex peptide structures for use in various biological and chemical applications.

InChI:InChI=1/C17H24N2O6/c1-6-11(2)14(18-16(21)25-17(3,4)5)15(20)24-13-9-7-12(8-10-13)19(22)23/h7-11,14H,6H2,1-5H3,(H,18,21)/t11-,14-/m0/s1

Upstream product

• 100-02-7 4-nitro-phenol 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 119439-57-5 C₄₉H₇₄N₁₄O₁₅ 
• 119439-66-6 C₂₁H₃₃N₇O₆*ClH 
• 119460-20-7 C₂₆H₄₁N₇O₈ 
• 105678-36-2 H-Ile-Gly-OBzl 
• 119439-58-6 C₅₈H₉₇N₁₇O₁₆S 
• 919518-62-0 methyl (2S,4R)-4-[({2-[(1R,3R)-1-acetoxy-4-methyl-3-{[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-2-methyl-5-phenylpentanoate 
• 944559-52-8 (2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester 
• 919518-56-2 4-nitrophenyl N-{[(2R)-1-methylpiperidin-2-yl]carbonyl}-L-isoleucinate 
• 94236-48-3 Boc-L-Ile-L-Asp(Bzl)-NH₂ 
• 90282-69-2 N-(tert-Butyloxycarbonyl)-L-isoleucyl-glycinbenzylester 
• 55382-08-6 Boc-Ile-Leu-OBzl 

Relevant articles and documents

SULFOXONIUM YLIDE DERIVATIVES AS PROBES FOR CYSTEINE PROTEASE

The present invention relates to compounds of formula I bearing a sulfoxonium ylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.