16952-66-2

Basic information

• Product Name: 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;4-AMINONICOTINIC ACID ETHYL ESTER;RARECHEM AL BI 1386;ethyl 4-aMinopyridine-3-carboxylate;4-Amino-3-ethoxycarbonylpyridine;Ethyl 4-amino-3-pyridinecarboxylate;Ethyl 4-aminonicotinate;3-Pyridinecarboxylic acid, 4-aMino-, ethyl ester
• CAS NO: 16952-66-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 16952-66-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 109-111℃
• Boiling Point: 300.6 °C at 760 mmHg
• Flash Point: 135.6 °C
• Appearance: /
• Density: 1.192
• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• PKA: 7.14±0.12(Predicted)
• CAS DataBase Reference: 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(16952-66-2)
• EPA Substance Registry System: 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(16952-66-2)

Safety Data

• Hazardous Substances Data: 16952-66-2(Hazardous Substances Data)

Usage

General Description

4-Aminopyridine-3-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H10N2O2. It is an ester derivative of 4-Aminopyridine-3-carboxylic acid, which is a pyridine derivative with potential pharmacological properties. 4-Aminopyridine-3-carboxylic acid ethyl ester has been studied for its potential use in the treatment of neurological disorders such as multiple sclerosis, as it has been shown to improve nerve conduction. It may also have applications in other fields such as organic synthesis and chemical research. 4-Aminopyridine-3-carboxylic acid ethyl ester is of interest to researchers and pharmaceutical companies for its potential therapeutic uses and its role in the development of new drugs.

InChI:InChI=1/C8H10N2O2/c1-2-12-8(11)6-5-10-4-3-7(6)9/h3-5H,2H2,1H3,(H2,9,10)

Upstream product

• 64-17-5 ethanol 
• 7418-65-7 4-aminonicotinic acid 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1078-05-3 4-nitro-3-carboxypyridine 1-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 141-97-9 ethyl acetoacetate 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 

Downstream Products

• 16952-64-0 pyrido[4,3-d]pyrimidin-4(3H)-one 
• 372951-29-6 ethyl 4-amido-(N-[3-phenoxy]phenylacetyl)nicotinate 
• 89533-20-0 4-aminonicotinoyl hydrazide 
• 1345539-89-0 ethyl 4-(2-fluorobenzamido)nicotinate 

Relevant articles and documents

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

A series of novel 1,3,4-oxadiazole thioether derivatives (compounds 9-44) were designed and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer agents. The in vitro anticancer activities of these compounds were evaluated against three cancer cell lines by the MTT method. Among all the designed compounds, compound 18 bearing a nitro substituent exhibited more potent in vitro anticancer activities with IC50 values of 0.7 ± 0.2, 30.0 ± 1.2, 18.3 ± 1.4 μM, respectively, which was superior to the positive control. In the further study, it was identified as the most potent inhibitor against two kinds of TS protein (for human TS and Escherichia coli TS, IC50 values: 0.62 and 0.47 μM, respectively) in the TS inhibition assay in vitro and the most potent antibacterial agents with MIC (minimum inhibitory concentrations) of 1.56-3.13 μg/mL against the tested four bacterial strains. Molecular docking and 3D-QSAR study supported that compound 18 can be selected as dual antitumor/antibacterial candidate in the future study.

9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) inhibitor activating pancreatic β cell protection and replication

Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote β cell protection and re

Facile synthesis of functionalized 4-aminopyridines

The title compounds are readily available by ring transformation of nitropyrimidinone with active methylene compounds in the presence of ammonium acetate.