1078-05-3

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Nitronicotinic acid N-oxide is used as a reagent in the synthesis of various pharmaceuticals. Its potent oxidizing properties make it a valuable component in the production of a wide range of medications.
Used in Agrochemical Production:
In the agrochemical industry, 4-Nitronicotinic acid N-oxide is utilized as a reagent for the synthesis of various agrochemicals. Its ability to act as a potent oxidizing agent contributes to the development of effective products for agricultural applications.
Used in Organic Synthesis:
4-Nitronicotinic acid N-oxide is employed as a reagent in organic synthesis across different industries. Its unique properties allow for the creation of a variety of organic compounds, making it a versatile component in chemical research and production.

InChI:InChI=1/C6H4N2O5/c9-6(10)4-3-7(11)2-1-5(4)8(12)13/h1-3H,(H,9,10)

Upstream product

• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 

Downstream Products

• 172225-04-6 4-nitro-3-pyridinecarboxanilide 1-oxide 
• 16952-66-2 4-amino-3-ethoxycarbonylpyridine 
• 372951-29-6 ethyl 4-amido-(N-[3-phenoxy]phenylacetyl)nicotinate 
• 93825-22-0 4-(4-chlorophenylthio)nicotinic acid 1-oxide 
• 93825-21-9 4-(phenylthio)nicotinic acid 1-oxide 
• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 177592-15-3 4-hydroxy-3-hydroxymethylpyridine 
• 16135-36-7 methyl 4-aminonicotinate 

Relevant academic research and scientific papers

Novel phenylalanine derivatives

Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists

A series of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [3H]5,7-dicholorokynurenic acid ([3H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (13i) is the most potent antagonist, having an IC50 value of 110 nM in [3H]DCKA binding and a Kb of 11 nM in the electrophysiology assay. Compound 13i is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED50 = 2.3 mg/kg, IP).

Antiviral thiazoles

Compounds of formula (I) are active antiviral compounds useful in the treatment of viral infections in mammals. The compounds of the invention are readily prepared by reaction of a suitable 2-thiothiazole derivative with an appropriate Het-(CH2)n -halide.

Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines

Dioxaphosphorino[m,n-x]pyridines compounds have been prepared by condensation of methyl dichlorophosphate with new ortho-hydroxymethylpyridinols.