7418-65-7

Basic information

• Product Name: 4-Amino-3-pyridinecarboxylic acid
• Synonyms: RARECHEM AL BE 1386;AURORA KA-2553;H-4ANIC-OH;IFLAB-BB F1957-0006;4-AMINO-3-CARBOXYPYRIDINE;4-AMINO-3-PYRIDINECARBOXYLIC ACID;4-AMINONICOTINIC ACID;4-AMINOPYRIDINE-3-CARBOXYLIC ACID
• CAS NO: 7418-65-7
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• EINECS: -0
• Product Categories: AMINOACID;Amines;blocks;Carboxes;Pyridines;Pyridine;pyridine derivative;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Organic acids;Pyridines derivates;Carboxylic Acids
• Mol File: 7418-65-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 307-312 °C
• Boiling Point: 253.51°C (rough estimate)
• Flash Point: 193.194 °C
• Appearance: Cream to yellow/Powder
• Density: 1.3471 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Soluble in aqueous acid and base.
• PKA: 2.94±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-pyridinecarboxylic acid(7418-65-7)
• EPA Substance Registry System: 4-Amino-3-pyridinecarboxylic acid(7418-65-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: N
• HazardClass: IRRITANT
• Hazardous Substances Data: 7418-65-7(Hazardous Substances Data)

Usage

Description

4-amino Nicotinic acid is a synthetic intermediate that has been used in various syntheses.

Chemical Properties

Light yellow Cryst

Uses

4-Aminonicotinic acid has been used in the preparation of 2-methyl-pyrido-oxazine. It is also used as pharmaceutical intermediate.

General Description

4-Amino-nicotinic acid is a white to light yellow and faint beige to light beige and faint brown to light brown powder or crystals.

InChI:InChI=1/C6H6N2O2/c7-5-1-2-8-3-4(5)6(9)10/h1-3H,(H2,7,8)(H,9,10)

Upstream product

• 67848-59-3 4-piperidone-3-carboxylic acid ethyl ester 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 

Downstream Products

• 16135-36-7 methyl 4-aminonicotinate 
• 16952-64-0 pyrido[4,3-d]pyrimidin-4(3H)-one 
• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 177592-15-3 4-hydroxy-3-hydroxymethylpyridine 
• 504-24-5 4-aminopyridine 
• 16952-66-2 4-amino-3-ethoxycarbonylpyridine 
• 1215074-43-3 2,4-dichloropyrido[4,3-d]pyrimidine 

Relevant articles and documents

Preparation method of nicotinic acid derivative

The invention relates to a preparation method of a nicotinic acid derivative. The method comprises the following steps: with N-benzylpiperidine-4-keto-3-formate as a raw material, carrying out a hydrogenolysis reaction to obtain piperidine-4-keto-3-formate; performing halogenation reaction with a certain amount of a halogenation reagent to obtain 3,5-dihalogenated piperidine-4-one-3-formate or 3,5,5-trihalogenated piperidine-4-one-3-formateperforming one-pot process with different alkaline reagent for removing halogen hydride through elimination, and performing hydrolysis and performing acidification with hydrochloric to generate corresponding nicotinic acid derivatives: 4-hydroxynicotinic acid, 4-aminonicotinic acid, 4-hydroxy-5-chloronicotinic acid, 4-amino-5-chloronicotinic acid and 4-amino-5-bromonicotinic acid. The method is simple and convenient to operate, mild in condition, short in technological process, low in wastewater amount, environmentally friendly and low in cost, and green industrial production of the nicotinic acid derivative is facilitated.