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Usage

Uses

Used in Antiviral Applications:
2-Thio-2'-Deoxycytidine is used as an antiviral agent for its ability to inhibit viral replication. The sulfur substitution in the molecule allows it to interfere with the normal functioning of viral enzymes, thus preventing the virus from replicating and spreading within the host organism. This property makes it a valuable tool in the development of new antiviral therapies.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Thio-2'-Deoxycytidine is used as a key intermediate in the synthesis of various antiviral drugs. Its unique structure and antiviral activity make it an attractive starting point for the development of new medications to combat viral infections, including those caused by emerging or drug-resistant strains of viruses.
Used in Research and Development:
2-Thio-2'-Deoxycytidine is also utilized in research and development settings to study the mechanisms of viral replication and the development of resistance to antiviral drugs. By understanding how 2-THIO-2'-DEOXYCYTIDINE interacts with viral enzymes and other cellular components, scientists can gain insights into the design of more effective antiviral therapies and strategies to combat viral infections.

Upstream product

• 333-49-3 2-thiocytosine 
• 98693-55-1 α-D-2′-deoxyribofuranose-1-O-phosphate bis(cyclohexylammonium) salt 

Relevant academic research and scientific papers

Synthesis and biological activity of 5-fluoro-2-thiocytosine nucleosides

Two pathways are described for the synthesis of the 2'-deoxynucleosides of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside condensation, (b) by amination of the corresponding nucleosides of 2,4- dithiouracil. Biological activities vs two cell systems are described. The nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the enzyme.

Method for producing a pyrimidine nucleoside compound and a new pyrimidine nucleoside compound

A method for producing a pyrimidine nucleoside compound includes reacting a sugar phosphate and pyrimidine base derivative using an enzyme having cytosine nucleoside phosphorylase activity, the pyrimidine base derivative being represented by general formula (I): (wherein R1 represents an amino group that may be replaced with an acyl group having an alkyl group of 1 to 3 carbon atoms or an alkyl group of 1 to 3 carbon atoms, an alkyl group of 1 to 3 carbon atoms, or a thiol group; R2 represents an amino group, a thiol group, a hydroxyl group, or a hydrogen atom; R3 represents an alkyl group of 1 to 3 carbon atoms that may be replaced with a hydroxyl group, an amino group, or a hydrogen atom; R4 represents a hydroxyl group or a hydrogen atom; when R1 is an amino group, when R2 is a hydroxyl group, and when R4 is a hydrogen atom; R3 is neither an alkyl group of 1 to 3 carbon atoms nor a hydrogen atom).