Synthesis and biological activity of 5-fluoro-2-thiocytosine nucleosides

Article abstract of DOI:10.1080/15257779508012445

Two pathways are described for the synthesis of the 2'-deoxynucleosides of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside condensation, (b) by amination of the corresponding nucleosides of 2,4- dithiouracil. Biological activities vs two cell systems are described. The nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the enzyme.

Full text of DOI:10.1080/15257779508012445

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Nucleosides and Nucleotides
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Synthesis and Biological Activity of 5-
Fluoro-2-thiocytosine Nucleosides
M. Bretner a , M. Balinska b , K. Krawiec a , B. Kierdaszuk c , D.
Shugar a & T. Kulikowski a
a Institute of Biochemistry and Biophysics, Polish Academy of
Sciences , 5a Pawinskiego St., 02-106, Warszawa, Poland
b Nencki Institute of Experimental Biology, Polish Academy of
Sciences , 3 Pasteur St., Warszawa, Poland
c Institute of Experimental Physics, University of Warsaw , 93 Zwirki
i Wigury St., 02-089, Warszawa, Poland
Published online: 16 Feb 2007.
To cite this article: M. Bretner , M. Balinska , K. Krawiec , B. Kierdaszuk , D. Shugar & T. Kulikowski
(1995) Synthesis and Biological Activity of 5-Fluoro-2-thiocytosine Nucleosides, Nucleosides and
Nucleotides, 14:3-5, 657-660
To link to this article: http://dx.doi.org/10.1080/15257779508012445
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