169772-25-2

Basic information

• Product Name: (tert-butylamino)(oxo)acetic acid
• Synonyms: (tert-butylamino)(oxo)acetic acid;acetic acid, [(1,1-dimethylethyl)amino]oxo-;Albb-009496;(tert-butylamino)(oxo)acetic acid(SALTDATA: FREE);2-(tert-butylamino)-2-keto-acetic acid;2-(tert-butylamino)-2-oxoacetic acid;2-(tert-butylamino)-2-oxo-acetic acid;2-(tert-butylamino)-2-oxo-ethanoic acid
• CAS NO: 169772-25-2
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Mol File: 169772-25-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.132g/cm³
• Refractive Index: 1.458
• CAS DataBase Reference: (tert-butylamino)(oxo)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (tert-butylamino)(oxo)acetic acid(169772-25-2)
• EPA Substance Registry System: (tert-butylamino)(oxo)acetic acid(169772-25-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 169772-25-2(Hazardous Substances Data)

Usage

General Description

The chemical (tert-butylamino)(oxo)acetic acid is a compound with the molecular formula C6H13NO3. It is a derivative of acetic acid, with a tert-butylamino group and an oxo (carbonyl) group attached to the carbon atom. (tert-butylamino)(oxo)acetic acid is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in the production of pharmaceuticals, agrochemicals, and other fine chemicals. The tert-butylamino group provides steric hindrance, making this compound valuable for the synthesis of complex molecules. Additionally, the oxo group adds reactivity, allowing for a wide range of chemical transformations and functionalization.

InChI:InChI=1/C6H11NO3/c1-6(2,3)7-4(8)5(9)10/h1-3H3,(H,7,8)(H,9,10)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 75-64-9 tert-butylamine 
• 87034-69-3 N-tert-butyloxanillic acid ethyl ester 

Downstream Products

• 1040762-80-8 C₁₉H₁₆BrClF₃N₃O₃ 
• 5894-65-5 N-t-butylbenzamide 
• 37486-48-9 N,N'-di-tert-butyloxamide 
• 1609-86-5 Tert-butyl isocyanate 

Relevant articles and documents

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid

A new, general, simple synthesis of isocyanates was developed by oxidation of monoamides of oxalix acid with peroxydisulfate catalyzed by Ag and Cu salts.The reaction was carried out in a two-phase system (water and an organic solvent), and it is suitable also for practical applications, due to the simple experimental conditions and the inexpensive as well as nontoxic reagents.The first example of homolytic intramolecular aromatic carbamoylation is also reported.