169774-63-4Relevant academic research and scientific papers
Towards a versatile synthesis of kainoids I: Introduction of the C-3 and C-4 substituents
Baldwin, Jack E.,Bamford, Samantha J.,Fryer, Andrew M.,Rudolph, Martin P. W.,Wood, Mark E.
, p. 5233 - 5254 (2007/10/03)
The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy-L-proline are described. An enamine alkylation was used to stereospecifically introduce the C-3 substituent, Grignard addition to a ketone or Pd(0) catalysed cross-coupling procedures adding C-4 aryl substituents for further manipulation. A number of versatile intermediates were generated.
A versatile approach to acromelic acid analogues
Baldwin, Jack E.
, p. 4869 - 4872 (2007/10/02)
A route to acromelic acid analogues and their corresponding C-4 epimers from trans-4-hydroxy-L-proline is described. The C-4 substituent was introduced by a Suzuki-type boronate coupling to a vinyl triflate.
