1698-61-9

Basic information

• Product Name: 4-AMINO-5-CHLORO-2-PHENYL-2H-PYRIDAZIN-3-ONE
• Synonyms: 4-AMINO-5-CHLORO-2-PHENYL-2H-PYRIDAZIN-3-ONE;4-aMino-5-chloro-2-phenylpyridazin-3(2H)-one;4-AMino-5-chloro-2-phenylpyridazin-3-one
• CAS NO: 1698-61-9
• Molecular Formula: C10H8ClN3O
• Molecular Weight: 221.65
• Mol File: 1698-61-9.mol

Chemical Properties

• Melting Point: 142.0-143.5 °C
• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.000538mmHg at 25°C
• Refractive Index: 1.667
• PKA: 0.85±0.20(Predicted)
• CAS DataBase Reference: 4-AMINO-5-CHLORO-2-PHENYL-2H-PYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-CHLORO-2-PHENYL-2H-PYRIDAZIN-3-ONE(1698-61-9)
• EPA Substance Registry System: 4-AMINO-5-CHLORO-2-PHENYL-2H-PYRIDAZIN-3-ONE(1698-61-9)

Safety Data

• Hazardous Substances Data: 1698-61-9(Hazardous Substances Data)

Usage

Uses

4-Amino-5-chloro-2-phenylpyridazin-3-one is a biologically non-active pyrazon isomer.

InChI:InChI=1/C10H8ClN3O/c11-8-6-13-14(10(15)9(8)12)7-4-2-1-3-5-7/h1-6H,12H2

Upstream product

• 1698-53-9 4,5-dichloro-1-phenylpyridazin-6-one 

Downstream Products

• 116538-67-1 SKI-187116 
• 116572-46-4 N-(5-Chloro-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-06-3 N-(5-Azocan-1-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-76-1 N-(5-Morpholin-4-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-75-0 N-(5-Diisobutylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-05-2 N-(5-Azepan-1-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-70-5 N-[5-(Butyl-ethyl-amino)-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl]-acetamide 
• 125291-73-8 N-(3-Oxo-2-phenyl-5-piperidin-1-yl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-68-1 N-(5-Dipropylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-04-1 N-(3-Oxo-2-phenyl-5-pyrrolidin-1-yl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-77-2 N-(5-Diethylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-72-7 N-(5-Dimethylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-09-6 4-Amino-5-diethylamino-2-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

Compounds for the Treatment of Neurodegeneration and Stroke

Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

SYNTHESIS, SPECTRAL PROPERTIES, AND PESTICIDAL ACTIVITY OF 4-AMINO(ALKYLAMINO, DIALKYLAMINO)-5-CHLORO-2-SUBSTITUTED-3-OXO-2H-PYRIDAZINES AND 5-AMINO(ALKYLAMINO, DIALKYLAMINO)-4-CHLORO-2-SUBSTITUTED-3-OXO-2H-PYRIDAZINES

4-Amino(alkylamino)-5-chloro-2-substituted-3-oxo-2H-pyridazines and 5-amino(alkylamino, dialkylamino)-4-chloro-2-substituted-3-oxo-2H-pyridazines have been prepared by nucleophilic substitution reactions of 4,5-dichloro-2-substituted-3-oxo-2H-pyridazines with amines in aprotic solvent.Structure of the compounds prepared has been proved by IR and UV spectra.Fungicidal and herbicidal activity of the compounds prepared have been tested.None of the compounds prepared exceeds the standard Vitavax in the fungicidal activity tests.Compounds VIII and XII show equal or better activity on the Hill reaction as compared with the standard pyrazone.