116572-46-4

Upstream product

• 75-36-5 acetyl chloride 
• 1698-61-9 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone 
• 109-89-7 diethylamine 
• 116538-67-1 SKI-187116 
• 110-96-3 diisobutylamine 
• 111-49-9 hexamethylene imine 
• 1121-92-2 heptamethyleneimine 
• 110-91-8 morpholine 
• 110-89-4 piperidine 
• 123-75-1 pyrrolidine 

Downstream Products

• 194016-04-1 N-(3-Oxo-2-phenyl-5-pyrrolidin-1-yl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-73-8 N-(3-Oxo-2-phenyl-5-piperidin-1-yl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-76-1 N-(5-Morpholin-4-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-06-3 N-(5-Azocan-1-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-05-2 N-(5-Azepan-1-yl-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-75-0 N-(5-Diisobutylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-70-5 N-[5-(Butyl-ethyl-amino)-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl]-acetamide 
• 125291-68-1 N-(5-Dipropylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-72-7 N-(5-Dimethylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 125291-77-2 N-(5-Diethylamino-3-oxo-2-phenyl-2,3-dihydro-pyridazin-4-yl)-acetamide 
• 194016-09-6 4-Amino-5-diethylamino-2-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Compounds for the Treatment of Neurodegeneration and Stroke

Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

Synthesis of novel 4-amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones

Substituted 4-amino-2-phenyl-2H-pyridazin-3-ones 5a-5j have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one 1 which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative 2 or 4-diacetylamino derivative 3, respectively. Derivatives 2 and 3 with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones 4a-4j. Subsequent alkaline hydrolysis of the acetylamino derivatives 4a-4j let to the title compounds 5a-5j, which were screened for pesticidal activity, but none of them reached activity of the used standards.