194016-06-3Relevant academic research and scientific papers
Synthesis of novel 4-amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones
Konecny, Vaclav,Zuziova, Jozefina,Kovac, Stefan,Liptaj, Tibor
, p. 800 - 808 (2007/10/03)
Substituted 4-amino-2-phenyl-2H-pyridazin-3-ones 5a-5j have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one 1 which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative 2 or 4-diacetylamino derivative 3, respectively. Derivatives 2 and 3 with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones 4a-4j. Subsequent alkaline hydrolysis of the acetylamino derivatives 4a-4j let to the title compounds 5a-5j, which were screened for pesticidal activity, but none of them reached activity of the used standards.
