253135-11-4

Upstream product

• 97966-29-5 methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate 
• 16980-82-8 3-(3-hydroxy-4-methoxyphenyl)-acrylic acid methyl ester 
• 129150-61-4 3-(3-hydroxy-4-methoxyphenyl)-propionic acid methyl ester 
• 621-59-0 isovanillin 
• 100-46-9 benzylamine 
• 1135-15-5 dihydroisoferulic acid 

Downstream Products

• 1459808-97-9 7,8-dihydroxy-N-(4-(phenyldiazenyl)phenethyl)-4,5-dihydro-1H-benzo[c]-azepine-2(3H)-carbothioamide 
• 1459809-07-4 7,8-dihydroxy-N-(4-((4-methoxyphenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide 
• 1459809-08-5 N-(4-((4-(diethylamino)phenyl)diazenyl)phenethyl)-7,8-di-hydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide 
• 1459809-09-6 7,8-dihydroxy-N-(4-((4-(trifluoromethyl)phenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide 
• 1459809-10-9 7,8-dihydroxy-N-(4-((4-nitrophenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo-[c]azepine-2(3H)-carbothioamide 
• 1459809-11-0 N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide 
• 253135-14-7 2-benzyl-7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-2-benzazepine 
• 253135-15-8 7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine 
• 253135-13-6 N-benzyl-3-(3-hydroxy-4-methoxyphenyl)propylamine 

Relevant academic research and scientific papers

A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist

A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist, has been accomplished from isovanillin in 8 steps via an efficient intramolecular Mannich cyclization.

Optical control of TRPV1 channels

Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity. Copyright