16985-34-5Relevant academic research and scientific papers
Facile synthesis, solublization studies and anti-inflammatory activity of amorphous zinc(Ii) centered aldimine complexes
Ali, Uzma,Alshater, Heba,Imran, Muhammad,Maalik, Aneela,Noor, Sadia,Qureshi, Ahmad Kaleem,Raheel, Ahmad,Sharif, Muhammad,Taj, Muhammad Babar,Tirmizi, Syed Ahmad
, p. 929 - 941 (2021/06/26)
In this study, Zn(II) centered complexes with aldimine derivatives were synthesized using green solvent, polyethylene glycol (PEG-400) and amorphous complexes were characterized by FT-IR, multinuclear (1H and13C NMR), elemental and thermal analysis. Thermogravimetric analysis indicated the extended thermal stability of the synthesized complexes. All the Zn(II) complexes show very significant photoexcitation in the range of 318 – 384 nm and photoemission in the range of 502 – 562 nm. Among all the complexes, Zn(II) complex (3Zn) showed minimum band gap value, 2.35 eV. These amorphous complexes have been reported for their wide applications in biomedical sciences. The synthesized aldimine ligands and Zn(II) complexes were investigated for anti-inflammatory activity and these complexes showed more anti-inflammatory potential than the corresponding aldimine ligands. The solubilization of zinc complexes in sodium dodecyl sulphate was also investigated to reveal the interaction of metal complexes by using UV-Visible spectroscopy and electrical conductivity measurements.
Synthesis and distinct urease enzyme inhibitory activities of metal complexes of Schiff-base ligands: Kinetic and thermodynamic parameters evaluation from TG-DTA analysis
Ikram, Muhammad,Rehman, Sadia,Faridoon,Baker, Robert J.,Rehman, Hanif Ur,Khan, Ajmal,Choudhary, Muhammad Iqbal,-Rehman, Saeed-Ur
, p. 72 - 80 (2013/04/23)
Transition metal [Co, Ni, Cu and Zn(II) acetates] complexes of salicylaldehyde derived Schiff bases, 2-{(E)-[(4-chlorophenyl)imino]methyl} phenol (CIMP) and 2-{(E)-[(4-bromophenyl)imino]methyl}phenol (BIMP) were synthesized and characterized by various analytical and spectroscopic studies. The Schiff base ligands and their metal complexes were also screened for their urease, α-chymotrypsin, acetylcholinesterse and butyrylcholinesterase inhibition activities. The ligands were found active against α-chymotrypsin with IC50 ± S.E.M. = 305.0 ± 3.2 and 330.6 ± 1.6 μM respectively. The copper complexes of both the ligands were found active in inhibiting urease enzyme with IC50 ± S.E.M. = 10.7 ± 0.2 and 5.0 ± 0.1 μM respectively, as compared to standard inhibitor. Structure activity relationship (SAR) was evaluated using autodock programme. It was found that the active complexes block the entrance cavity to the enzyme. All the complexes were evaluated for their thermal degradation studies using TG-DTA analytical methods in static air. Thermodynamic and kinetic parameters were evaluated from the TG/DTA curves using Horowitz-Metzger method.
