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Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2,4-dimethoxyaniline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-2,4-dimethoxyaniline serves as a crucial component in the production of agrochemicals, aiding in the creation of compounds that can protect crops and enhance agricultural productivity.
Used in Antimalarial Research:
5-Bromo-2,4-dimethoxyaniline is utilized as a subject of investigation in antimalarial studies, exploring its potential to combat malaria, a significant global health concern.
Used in Antitumor Research:
5-Bromo-2,4-dimethoxyaniline is also employed in antitumor research, examining its capacity to inhibit tumor growth and contribute to cancer treatment strategies.
Safety Precautions:
It is essential to handle 5-Bromo-2,4-dimethoxyaniline with care due to its potential hazards. It may be harmful if ingested, inhaled, or absorbed through the skin, and it can cause eye and skin irritation. Proper safety measures should be taken during its synthesis and use to minimize health risks.

Upstream product

• 2735-04-8 2,4-Dimethoxyaniline 
• 778599-56-7 1-bromo-2,4-dimethoxy-5-nitrobenzene 
• 4920-84-7 2,4-dimethoxynitrobenzene 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 1276581-99-7 1-azido-5-bromo-2,4-dimethoxybenzene 
• 1276582-20-7 4,4'-(2,5-dimethoxy-1,4-phenylene)bis(1-(5-bromo-2,4-dimethoxyphenyl)-1H-1,2,3-triazole) 
• 625119-44-0 1-bromo-5-isocyanato-2,4-dimethoxybenzene 

Relevant academic research and scientific papers

Designing Structural Motifs for Clickamers: Exploiting the 1,2,3-Triazole Moiety to Generate Conformationally Restricted Molecular Architectures

Noncovalent interactions, especially hydrogen-bonding interactions as well as electrostatic forces, confined within one macromolecule are the key to designing foldamers that adopt well-defined conformations in solution. In the context of significant recent activities in the area of triazole-connected foldamers, so-called clickamers, we present a fundamental study that compares various model compounds that bear adjacent N-, O-, or F-heteroatom substituents. The interplay of attractive and repulsive interactions leads to rotational constraints around the single bonds attached to both the 1- and 4-positions of the 1,2,3-triazole moiety and should therefore be able to induce well-defined conformational preferences in higher oligomers and polymers, that is, foldamers. Various compounds were synthesized and characterized with regard to their preferred conformations in all three aggregation statesa-that is, in the gas phase, in solution as well as in the solid statea-by employing DFT calculations, NMR spectroscopic experiments, and X-ray crystallography, respectively. On the basis of the thus-obtained general understanding of the conformational behavior of the individual connection motifs, heterostructures were prepared from different motifs without affecting their distinct folding characteristics. Therefore, this work provides a kind of foldamer construction kit, which should enable the design of various clickamers with specific shape and incorporated functionality. A foldamer construction kit: Various heterostructures "clicked" together by structure-directing triazole moieties were investigated with regard to their conformational behavior. Different heteroatoms (X; see graphic) can be used to bias the conformation around the N(1)- and C(4)-connecting single bonds of the triazoles based on tunable noncovalent interactions.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R 1, R 3, R 4, R 5, Z, Y, V, X, X', J, K, L, and M are as defined herein.

1N-alkyl-N-arylpyrimidinamines and derivatives thereof

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X', J, K, L, and M are as defined herein.