169883-36-7

Basic information

• Product Name: 5-Bromo-2,4-dimethoxyaniline
• Synonyms: 3-Bromo-4,6-dimethoxyaniline;5-Bromo-2,4-dimethoxyaniline
• CAS NO: 169883-36-7
• Molecular Formula: C₈H₁₀BrNO₂
• Molecular Weight: 232.0745
• Mol File: 169883-36-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 316.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.07±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-2,4-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,4-dimethoxyaniline(169883-36-7)
• EPA Substance Registry System: 5-Bromo-2,4-dimethoxyaniline(169883-36-7)

Safety Data

• Hazardous Substances Data: 169883-36-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,4-dimethoxyaniline is a chemical compound with the molecular formula C8H10BrNO2. It is an organic compound that contains a bromine atom, two methoxy groups, and an aniline group. 5-Bromo-2,4-dimethoxyaniline is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It has also been investigated for its potential antimalarial and antitumor activities. 5-Bromo-2,4-dimethoxyaniline is typically synthesized through the bromination of 2,4-dimethoxyaniline, and it is commonly used as an intermediate in the production of other organic compounds. It is important to handle 5-Bromo-2,4-dimethoxyaniline with caution, as it may be harmful if swallowed, inhaled, or absorbed through the skin, and it can cause irritation to the eyes and skin.

Upstream product

• 2735-04-8 2,4-Dimethoxyaniline 
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Downstream Products

• 1276581-99-7 1-azido-5-bromo-2,4-dimethoxybenzene 
• 1276582-20-7 4,4'-(2,5-dimethoxy-1,4-phenylene)bis(1-(5-bromo-2,4-dimethoxyphenyl)-1H-1,2,3-triazole) 
• 625119-44-0 1-bromo-5-isocyanato-2,4-dimethoxybenzene 

Relevant articles and documents

Designing Structural Motifs for Clickamers: Exploiting the 1,2,3-Triazole Moiety to Generate Conformationally Restricted Molecular Architectures

Noncovalent interactions, especially hydrogen-bonding interactions as well as electrostatic forces, confined within one macromolecule are the key to designing foldamers that adopt well-defined conformations in solution. In the context of significant recent activities in the area of triazole-connected foldamers, so-called clickamers, we present a fundamental study that compares various model compounds that bear adjacent N-, O-, or F-heteroatom substituents. The interplay of attractive and repulsive interactions leads to rotational constraints around the single bonds attached to both the 1- and 4-positions of the 1,2,3-triazole moiety and should therefore be able to induce well-defined conformational preferences in higher oligomers and polymers, that is, foldamers. Various compounds were synthesized and characterized with regard to their preferred conformations in all three aggregation statesa-that is, in the gas phase, in solution as well as in the solid statea-by employing DFT calculations, NMR spectroscopic experiments, and X-ray crystallography, respectively. On the basis of the thus-obtained general understanding of the conformational behavior of the individual connection motifs, heterostructures were prepared from different motifs without affecting their distinct folding characteristics. Therefore, this work provides a kind of foldamer construction kit, which should enable the design of various clickamers with specific shape and incorporated functionality. A foldamer construction kit: Various heterostructures "clicked" together by structure-directing triazole moieties were investigated with regard to their conformational behavior. Different heteroatoms (X; see graphic) can be used to bias the conformation around the N(1)- and C(4)-connecting single bonds of the triazoles based on tunable noncovalent interactions.

1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R 1, R 3, R 4, R 5, Z, Y, V, X, X', J, K, L, and M are as defined herein.