778599-56-7

Upstream product

• 4920-84-7 2,4-dimethoxynitrobenzene 
• 860242-93-9 2-bromo-3,5-dimethoxy-6-nitro-benzaldehyde 
• 875235-16-8 4-bromo-6-nitro-resorcinol 
• 77-78-1 dimethyl sulfate 
• 633357-97-8 4-bromo-5-methoxy-2-nitro-phenol 
• 6468-19-5 2,4-dimethoxy-5-nitrobenzaldehyde 
• 90564-41-3 2,4-dimethoxy-5-nitrobenzoic acid 
• 7726-95-6 bromine 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 345-24-4 5-bromo-2,4-difluoronitrobenzene 
• 124-41-4 sodium methylate 
• 151-10-0 1,3-Dimethoxybenzene 
• 85565-93-1 2-bromo-3,5-dimethoxy-benzaldehyde 

Downstream Products

• 169883-36-7 5-bromo 2,4-dimethoxy aniline 
• 1276581-99-7 1-azido-5-bromo-2,4-dimethoxybenzene 
• 1276582-20-7 4,4'-(2,5-dimethoxy-1,4-phenylene)bis(1-(5-bromo-2,4-dimethoxyphenyl)-1H-1,2,3-triazole) 
• 878160-20-4 4-(2,4-dimethoxy-5-nitrophenyl)morpholine 

Relevant academic research and scientific papers

Electrophilic aryl-halogenation using N-halosuccinimides under ball-milling

We report here a methodology of chemo- and regio-selective aryl bromination and iodination using respective N-halosuccinimides at room temperature in the absence of any solvents, catalyst/additives under ball-milling condition. However, for chlorination ceric ammonium nitrate was used as additive. The coupled product succinimide, produced from the reactions, was recycled via regeneration of NBS. This methodology works with the electron-donor substituted or unsubstituted arenes.

Electrophilic aryl-halogenation using N-halosuccinimides under ball-milling

We report here a methodology of chemo- and regio-selective aryl bromination and iodination using respective N-halosuccinimides at room temperature in the absence of any solvents, catalyst/additives under ball-milling condition. However, for chlorination ceric ammonium nitrate was used as additive. The coupled product succinimide, produced from the reactions, was recycled via regeneration of NBS. This methodology works with the electron-donor substituted or unsubstituted arenes.

Designing Structural Motifs for Clickamers: Exploiting the 1,2,3-Triazole Moiety to Generate Conformationally Restricted Molecular Architectures

Noncovalent interactions, especially hydrogen-bonding interactions as well as electrostatic forces, confined within one macromolecule are the key to designing foldamers that adopt well-defined conformations in solution. In the context of significant recent activities in the area of triazole-connected foldamers, so-called clickamers, we present a fundamental study that compares various model compounds that bear adjacent N-, O-, or F-heteroatom substituents. The interplay of attractive and repulsive interactions leads to rotational constraints around the single bonds attached to both the 1- and 4-positions of the 1,2,3-triazole moiety and should therefore be able to induce well-defined conformational preferences in higher oligomers and polymers, that is, foldamers. Various compounds were synthesized and characterized with regard to their preferred conformations in all three aggregation statesa-that is, in the gas phase, in solution as well as in the solid statea-by employing DFT calculations, NMR spectroscopic experiments, and X-ray crystallography, respectively. On the basis of the thus-obtained general understanding of the conformational behavior of the individual connection motifs, heterostructures were prepared from different motifs without affecting their distinct folding characteristics. Therefore, this work provides a kind of foldamer construction kit, which should enable the design of various clickamers with specific shape and incorporated functionality. A foldamer construction kit: Various heterostructures "clicked" together by structure-directing triazole moieties were investigated with regard to their conformational behavior. Different heteroatoms (X; see graphic) can be used to bias the conformation around the N(1)- and C(4)-connecting single bonds of the triazoles based on tunable noncovalent interactions.

PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors . Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

PYRIMIDINE DERIVATIVES

Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.