169889-40-1

Upstream product

• 170080-33-8 N-(benzyloxycarbonyl)-7α,8α-epoxy-9-azabicyclo<4.2.1>nonane 
• 169889-44-5 N-(benzyloxycarbonyl)-7β,8β-epoxy-9-azabicyclo<4.2.1>nonane 
• 139682-26-1 N-methyl-9-azabicyclo[4.2.1]non-7-ene 
• 51787-59-8 9-Azabicyclo[4.2.1]non-7-ene 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 169889-44-5 N-(benzyloxycarbonyl)-7β,8β-epoxy-9-azabicyclo<4.2.1>nonane 

Relevant academic research and scientific papers

Stereoselective Oxygenation of the Homotropane Ring System; Synthesis of Exo- and Endo-7-Hydroxy- and 7,8-Epoxyhomotropanes

Stereoselective introduction of an endo- epoxide into the 2-carbon bridge of the homotropane (9-azabicyclononane) ring system has been achieved via a 4-aminocyclooct-2-enol derivative; the direct route to the exo- analogue from 7,8-dehydrohomotropa

Synthesis and nicotinic acetylcholine-binding properties of epibatidine homologues: Homoepibatidine and dihomoepibatidine

Homoepibatidine 2 and dihomoepibatidine 3 have been synthesised from the 8-azabicyclo[3.2.1]oct-6-ene 8 and the 9-azabicyclo[4.2.1]oct-7-ene 9, respectively, the key precursors for reductive Heck coupling reactions. Alternative routes starting from cyclohepta- and cycloocta-1,3-diene are described; deoxygenation of tropane and homotropane epoxides provides a convenient route to 8 and 9. The enantiomers of 2 show similar potency at nicotinic receptors to the corresponding epibatidine enantiomers; the affinity of 3 is lower.