Stereoselective Oxygenation of the Homotropane Ring System; Synthesis of Exo- and Endo-7-Hydroxy- and 7,8-Epoxyhomotropanes

Article abstract of DOI:10.1016/0040-4039(95)00835-Z

Stereoselective introduction of an endo- epoxide into the 2-carbon bridge of the homotropane (9-azabicyclo<4.2.1>nonane) ring system has been achieved via a 4-aminocyclooct-2-enol derivative; the direct route to the exo- analogue from 7,8-dehydrohomotropa