1699-59-8

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dibenzyloxybenzyl chloride is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block in the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 3,4-Dibenzyloxybenzyl chloride is used as a precursor for the preparation of benzylnitrile, which is an essential compound in the synthesis of amidines. Amidines are important in the development of various chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Due to its unique chemical properties and structure, 3,4-Dibenzyloxybenzyl chloride is also utilized in research and development for the exploration of new chemical reactions and the creation of novel compounds with potential applications in various industries, such as materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C21H19ClO2/c22-14-19-11-12-20(23-15-17-7-3-1-4-8-17)21(13-19)24-16-18-9-5-2-6-10-18/h1-13H,14-16H2

Upstream product

• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 882427-72-7 3,4-(bisbenzyloxy)benzoic acid benzyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1699-58-7 3,4-bis(benzyloxy)benzyl alcohol 

Downstream Products

• 113756-42-6 8-benzyloxy-N-benzoyl-1-(3',4'-dibenzyloxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 
• 121102-14-5 N-<3,4-bis(benzyloxy)benzyl>ethylenediamine 
• 1699-60-1 (3,4-bis-benzyloxyphenyl)acetonitrile 
• 77564-63-7 2-Benzyl-5,7-bis-benzyloxy-1-(3,4-bis-benzyloxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline 
• 959619-02-4 C₃₇H₃₉N₃O₆ 
• 96826-02-7 1-(3,4-dihydroxybenzyl)imidazoline hydrochloride 
• 96826-09-4 1-<3,4-bis(benzyloxy)benzyl>imidazoline hydrochloride 
• 82071-48-5 1-(3,4-dihydroxyphenylmethyl)-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine 
• 178415-79-7 (2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(3,4-dibenzyloxybenzyl)pyrrolidine-2,4-dicarboxylate 

Relevant academic research and scientific papers

Caffeinated compounds and compositions for treatment of amyloid diseases and synucleinopathies

Compounds and their pharmaceutically acceptable salts for treatment of β-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease.

Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.

CAFFEINATED COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES

Compounds and their pharmaceutically acceptable salts for treatment of Beta-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.