1699-62-3

Upstream product

• 1699-61-2 <3,4-bis(benzyloxy)phenyl>acetic acid 
• 55536-65-7 3,4-di(benzyloxy)phenethylamine 
• 1699-54-3 3,4-bis(benzyloxy)-β-nitrostyrene 
• 1699-60-1 (3,4-bis-benzyloxyphenyl)acetonitrile 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1699-58-7 3,4-bis(benzyloxy)benzyl alcohol 
• 1699-59-8 3,4-dibenzyloxybenzyl chloride 
• 1699-54-3 (E)-3,4-dibenzyloxy-β-nitrostyrene 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 1932-43-0 6,7-bisbenzyloxy-1-(3,4-bisbenzyloxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 79831-95-1 NN-bis-(3,4-dibenzyloxyphenethyl)amine hydrochloride 
• 79831-99-5 NN-bis-(3,4-dihydroxyphenethyl)amine hydrochloride 
• 3184-36-9 norlaudanosoline hydrochloride 
• 54781-85-0 6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 79832-14-7 6,7-bisbenzyloxy-1-(3,4-bisbenzyloxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 

Relevant academic research and scientific papers

Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease

Currently, influenza PAN endonuclease has become an attractive target for development of new drugs to treat influenza infections. Herein we report the discovery of new PAN endonuclease inhibitors derived from a chelating agent dopamine moiety. A series of dopamine amide derivatives and their conformationally constrained 1,2,3,4-tetrahydroisoquinoline-6,7-diol-based analogs were elaborated and assayed against influenza virus A/WSN/33 (H1N1). Most compounds exhibited moderate to excellent antiviral activities, generating a preliminary SARs. Among them, compounds 14 and 19 showed stronger anti-IAV activity compared with the reference Peramivir. Moreover, 14 and 19 demonstrated a concentration-dependent inhibition of PAN endonuclease based on both FRET assay and SPR assay. Docking studies were also performed to elucidate the binding mode of 14 and 19 with the PAN protein and to identify amino acids involved in their mechanism of action, which were well consistent with the biological data. This finding was beneficial to laying the foundation for the rational development of more effective PAN endonuclease inhibitors.

Biosynthesis. Part 24. Speculative Incorporation Experiments with 1-Benzylisoquinolines and a Logical Approach via C6-C2 and C6-C3 Precursors to the Biosynthesis of Hasubanonine and Protostephanine

Many possible 1-benzyltetrahydroisoquinolines have been examined as possible advanced precursors of the alkaloids hasubanonine (1) and protostephanine (2) in Stephania japonica plants, but none was incorporated significantly.Administration of various precursor molecules having only one aromatic ring, such as tyrosine, has demonstrated that both alkaloids are derived from two different C6-C2 biogenetic units.The subsequent failure of further 1-benzyltetrahydroisoquinolines and bisphenethylamines to be incorporated suggested the intermediacy of either (a) modified 1-benzylisoquinolines or (b) trioxygenated C6-C2 building blocks.Precursors designed to examine the first possibility, such as 1-benzyl-3,4-dihydroisoquinolines or 1-benzyl-1-carboxytetrahydroisoquinolines, were not incorporated into (1) and (2) whereas two 3',4',5'-trioxygenated 2-phenylethylamines were incorporated.These findings allow further delineation of the requirements for later precursors of the alkaloids (1) and (2).