169903-68-8

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 67-64-1 acetone 

Downstream Products

• 181519-96-0 7,11-Bis-(3-bromo-phenyl)-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone 
• 181520-18-3 7,11-Bis-(3-bromo-phenyl)-2,4-diaza-spiro[5.5]undecane-1,3,5,9-tetraone 9-oxime 
• 1217056-08-0 C₂₀H₁₅Br₂NO₄ 
• 1309883-38-2 ethyl (2R,6R)-2,6-bis(3-bromophenyl)-2',4-dioxospiro[cyclohexane-1,3'-indoline]-1'-carboxylate 
• 1387581-35-2 C₃₀H₂₇Br₂NO₄ 
• 1383951-46-9 C₂₃H₁₉Br₂OP 

Relevant academic research and scientific papers

Study of substituent effects in substituted dibenzal acetones

The present work involves a detailed study of the ultra-violet absorption spectra of various substituted dibenzylidene ketones derived from acetone, ethyl methyl ketone, diethyl ketone, cyclopentanone and cyclohexanone by condensing with several meta- and para-substituted benzaldehydes in n-hexane and in ethanol to ascertain the transition dominant in these solvents. These ketones exist as equilibrium mixtures of s-cis, cis and s-cis, trans conformations. The ultraviolet absorption spectra of the ketones exhibit two bands due to π* ← π transition around 250 and 320 nm. The 320 nm band is prominent in all the cases. There is no indication of π* ← n transition in any of the spectra. The 320 nm band is structureless in all the cases except those shown by the dibenzylidene ketones derived from cyclopentanone in hexane. Therefore it can be inferred that the dibenzylide ketones derived from all the ketones except those derived from cyclopentanone are non-planar.

Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric acids: Part I

Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric and thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by treatment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.