169939-94-0

Basic information

• Product Name: RUBOXISTAURIN MESYLATE
• Synonyms: 9H,18H-5,21:12,17-Dimethenodibenzo(E,K)pyrrolo(3,4-H)(1,4,13)oxadiazacyclohexadecine-18,20(19H)-dione, 9-((dimethylamino)methyl)-6,7,10,11-tetrahydro-, (9S)-;Unii-721809wqcp;Ruboxistaurin (LY333531);Ruboxistaurin (LY333531) (HCl salt);RUBOXISTAURIN MESYLATE;(S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione;LY 333531;Ruboxistaurin
• CAS NO: 169939-94-0
• Molecular Formula: C28H28N4O3
• Molecular Weight: 468.54692
• Mol File: 169939-94-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 744.4 °C at 760 mmHg
• Flash Point: 404 °C
• Appearance: /
• Density: 1.34
• Vapor Pressure: 4.93E-22mmHg at 25°C
• Refractive Index: 1.695
• PKA: 8.26±0.40(Predicted)
• CAS DataBase Reference: RUBOXISTAURIN MESYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: RUBOXISTAURIN MESYLATE(169939-94-0)
• EPA Substance Registry System: RUBOXISTAURIN MESYLATE(169939-94-0)

Safety Data

• Hazardous Substances Data: 169939-94-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1

Upstream product

• 1224599-85-2 (R)-6,7,10,11-tetrahydro-9-[(dimethylamino)methyl]-5,21:12,17-dimetheno-9H-dibenzo[e,k]furo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione 
• 68-12-2 N,N-dimethyl-formamide 
• 169940-46-9 (9S)-6,7,10,11-tetrahydro-9-{[(methylsulfonyl)oxy]methyl}-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione 
• 124-40-3 dimethyl amine 
• 169940-41-4 (S)-3-Allyloxy-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester 
• 169940-43-6 (S)-3-Allyloxy-4-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol 
• 169940-42-5 tert-Butyl-[(S)-4-iodo-2-(2-iodo-ethoxy)-butoxy]-diphenyl-silane 
• 169940-44-7 (S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-(2-hydroxy-ethoxy)-butan-1-ol 
• 183198-55-2 Methanesulfonic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester 
• 169940-55-0 (9S)-6,7,10,11-tetrahydro-9-(hydroxymethyl)-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13 ]-oxadiazacyclohexadecine-18,20(19H)-dione 

Relevant articles and documents

Method of manufacturing ruboxistarin

Method of manufacturing ruboxistaurin, comprising the steps of preparation of L-2-deoxyribose 1-cyano-3,4-dibenzoate, followed by deprotection to 1-cyano L-2-deoxyribose, oxidative cleaving to (S)-4-hydroxy-2-(2-hydroxy-ethoxy)-butyronitrile and transform

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21- dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene- 1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ

Protein kinase C (PKC) is a family of closely related serine and threonine kinases. Overactivation of some PKC isozymes has been postulated to occur in several disease states, including diabetic complications. Selective inhibition of overactivated PKC iso