169954-67-0Relevant academic research and scientific papers
Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers
Fremaux, Juliette,Dolain, Christel,Kauffmann, Brice,Clayden, Jonathan,Guichard, Gilles
, p. 7415 - 7417 (2013)
The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic
Tricyclic compound, pharmaceutical composition and application thereof
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, (2021/08/07)
The present invention provides a tricyclic compound, an isomer thereof, a pharmaceutically acceptable salt, a pharmaceutical composition and an application thereof. The tricyclic compound has a structure represented by formula I, has a significant effect of inhibiting RET kinase activity, can effectively inhibit cancer cell proliferation, can be used as an RET kinase inhibitor, can be used for preparing medicines for treating RET kinase-mediated diseases, has a good treatment effect on RET kinase-mediated cancers and other diseases, and has a wide application prospect.
allah Geleg sandbank method for the preparation of intermediates
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Paragraph 0033; 0034, (2017/02/24)
The invention relates to a preparation method of Anagliptin intermediates (2-amino-2-methyl-propyl)-benzyl carbamate and (2-amino-1, 1-dimethyl-ethyl)-tert-butyl carbamate, wherein the preparation method is short in reaction period, simple to operate, eas
NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
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, (2011/11/06)
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multipl
