170028-71-4Relevant academic research and scientific papers
Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors
Kaltenbach III, Robert F.,Patel, Mona,Waltermire, Robert E.,Harris, Gregory D.,Stone, Benjamin R. P.,Klabe, Ronald M.,Garber, Sena,Bacheler, Lee T.,Cordova, Beverly C.,Logue, Kelly,Wright, Matthew R.,Erickson-Viitanen, Susan,Trainor, George L.
, p. 605 - 608 (2007/10/03)
A series of P1/P1′ substituted cyclic urea analogues were prepared in an attempt to increase the intra-cellular antiviral potency of the nonsymmetrical 3-aminoindazoles DMP 850 and DMP 851. The effect of alkyl substitution of the P1/P1′ residues on cellul
A Practical Synthesis of Nonpeptide Cyclic Ureas as Potent HIV Protease Inhibitors
Rossano, Lucius T.,Lo, Young S.,Anzalone, Luigi,Lee, Ying-Chi,Meloni, David J.,et al.
, p. 4967 - 4970 (2007/10/02)
The utilization of the oxydimethylene group to form a trioxepane ring for the protection of 1,2-diols was demonstrated.A process starting with natural L-tartaric acid as the chiral building block is utilized in the synthesis of optically active, nonpeptid
