1701-19-5

Usage

Uses

Used in Chemical Synthesis:
4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE is used as a building block for the synthesis of other compounds, contributing to the creation of a diverse range of chemical products.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE is used as a reagent in organic chemistry reactions, playing a crucial role in the development of new drugs and medicinal compounds.
Used in Organic Chemistry:
4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE is employed as a reagent in various organic chemistry reactions, facilitating the synthesis of complex molecules and contributing to the advancement of chemical research.
Used in Fluorine Chemistry:
The presence of the trifluoromethyl group in 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE imparts unique and useful properties to the compound, making it valuable in fluorine chemistry applications, where fluorinated compounds are of high interest due to their distinct chemical and physical properties.

InChI:InChI=1/C11H8F3NO/c1-6-3-2-4-7-8(16)5-9(11(12,13)14)15-10(6)7/h2-5H,1H3,(H,15,16)

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 95-53-4 o-toluidine 

Downstream Products

• 1701-25-3 4-chloro-8-methyl-2-trifluoromethyl-quinoline 

Relevant academic research and scientific papers

Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission

Achieving the desired structures of organic molecules for targeted applications is vital. Folding caused by weak intermolecular forces plays an important part in their 3D structure. Powerful tools which enable us to do this are currently under investigation by researchers across the globe. On this account, quinoline was chosen as a model scaffold because of its rigid 3D structure. Addition of fluorine was found to result in increased flexibility of the structure with a decrease in the number of intermolecular interactions. This resulted in improvement of their photophysics and blue emission. A total of 19 novel fluoroquinoline molecules were synthesised in order to carry out this study. Of these, grown crystals of 10 compounds were successfully achieved and used. In addition, characterisation techniques such as NMR, HRMS, UV-vis and computational techniques were used to explore the 3D structure of these molecules.

ANTIBIOTIC COMPOSITIONS

The present disclosure relates to compounds having antimicrobial activity, compositions comprising said compounds in combination with β-lactam antibiotics, and methods of using the compounds and compositions.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.