1701-25-3 Usage
General Description
4-Chloro-8-methyl-2-(trifluoromethyl)quinoline is a chemical compound containing a quinoline ring with a chlorine and a methyl group on the 4th and 8th positions, and a trifluoromethyl group on the 2nd position. It is a halogenated quinoline derivative with potential biological and pharmaceutical applications. 4-Chloro-8-methyl-2-(trifluoromethyl)quinoline has been studied for its antimicrobial and antimalarial properties, as well as its potential use in drug discovery and development. It is also used as a building block in the synthesis of various organic compounds and pharmaceuticals. However, its full spectrum of biological activity and potential toxic effects are still being explored.
Check Digit Verification of cas no
The CAS Registry Mumber 1701-25-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,0 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1701-25:
(6*1)+(5*7)+(4*0)+(3*1)+(2*2)+(1*5)=53
53 % 10 = 3
So 1701-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H7ClF3N/c1-6-3-2-4-7-8(12)5-9(11(13,14)15)16-10(6)7/h2-5H,1H3
1701-25-3Relevant articles and documents
Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission
Alapour,Zamisa,Silva,Alves,Omondi,Ramjugernath,Koorbanally
, p. 2316 - 2323 (2018/04/30)
Achieving the desired structures of organic molecules for targeted applications is vital. Folding caused by weak intermolecular forces plays an important part in their 3D structure. Powerful tools which enable us to do this are currently under investigation by researchers across the globe. On this account, quinoline was chosen as a model scaffold because of its rigid 3D structure. Addition of fluorine was found to result in increased flexibility of the structure with a decrease in the number of intermolecular interactions. This resulted in improvement of their photophysics and blue emission. A total of 19 novel fluoroquinoline molecules were synthesised in order to carry out this study. Of these, grown crystals of 10 compounds were successfully achieved and used. In addition, characterisation techniques such as NMR, HRMS, UV-vis and computational techniques were used to explore the 3D structure of these molecules.
