β-Ethoxyvinyl polyfluoroalkyl ketones - versatile synthones in fluoroorganic chemistry

Article abstract of DOI:10.1016/0022-1139(94)03130-4

We have found readily available β-ethoxyvinyl trifluoromethyl ketone to be a convenient and comprehensive starting material for the synthesis of various fluoro-containing compounds such as heterocycles, enones, enaminones and chelate complexes.The 4,4,4-trifluoro-3-oxo-1-butenyl group formed by β-ethoxyvinyl trifluoromethyl ketone is a suitable protecting group for the N-H terminal of amino acids in peptide synthesis.The formation of peptides using these protected amino acids occurs without racemization. - Keywords: β-Ethoxyvinyl polyfluoroalkyl ketones; Synthones; Protecting group; Peptide synthesis; Reactions