170119-37-6

Basic information

• Product Name: (4-Chloro-phenyl)-methoxycarbonylamino-acetic acid
• CAS NO: 170119-37-6
• Molecular Weight: 243.647
• Mol File: 170119-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-Chloro-phenyl)-methoxycarbonylamino-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chloro-phenyl)-methoxycarbonylamino-acetic acid(170119-37-6)
• EPA Substance Registry System: (4-Chloro-phenyl)-methoxycarbonylamino-acetic acid(170119-37-6)

Safety Data

• Hazardous Substances Data: 170119-37-6(Hazardous Substances Data)

Upstream product

• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 79-22-1 methyl chloroformate 
• 6212-32-4 5-(p-chlorophenyl)hydantoin 

Downstream Products

• 170119-35-4 Acetic acid {[1-(4-chloro-phenyl)-2-pyrrolidin-1-yl-ethyl]-methyl-carbamoyl}-(3,4-dichloro-phenyl)-methyl ester 
• 170119-33-2 [1-(4-Chloro-phenyl)-2-pyrrolidin-1-yl-ethyl]-methyl-amine 

Relevant articles and documents

Synthesis and κ binding affinity of 1-(pyrrolidin-1-ylmethyl)-2-(N-methyl)-4--1,2,3,4-tetrahydroisoquinolin-3(2H)-ones

Diastereomeric forms of 1-(pyrrolidin-1-ylmethyl)-2-(N-methyl)-4--1,2,3,4-tetrahydroisoquinolin-3-(2H)-ones 3a and its chloro analog 3c were synthesized.Compounds 3a,c are related to the κ-selective opiate ICI 199441 1 by linking the benzylic CH2 to the ortho position of the phenyl in 1.Compared with morphine, these compounds had lost in κ and μ affinities; only cis-3a showed a modest κ affinity. 1-Pyrrolidin-1-ylmethyl-N--1,2,3,4-tetrahydroisoquinoline 2, which is also a cyclic congener of 1, was reported to display high κ and μ affinity, and so a conformational study was undertaken on 1, 2 and 3a.This showed that while active 2 extensively superposed on 1, 3a assumes another geometry which does now allow a fit with the pharmacophoric moieties of 1 and 2. tetrahydroisoquinolin-3(2H)-one / κ-opiate receptor / rigid congener