6212-32-4

Basic information

• Product Name: 5-(4-chlorophenyl)imidazolidine-2,4-dione
• CAS NO: 6212-32-4
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.6171
• Mol File: 6212-32-4.mol
• Article Data: 4

Chemical Properties

• Density: 1.404g/cm³
• Refractive Index: 1.583
• CAS DataBase Reference: 5-(4-chlorophenyl)imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)imidazolidine-2,4-dione(6212-32-4)
• EPA Substance Registry System: 5-(4-chlorophenyl)imidazolidine-2,4-dione(6212-32-4)

Safety Data

• Hazardous Substances Data: 6212-32-4(Hazardous Substances Data)

Usage

General Description

5-(4-chlorophenyl)imidazolidine-2,4-dione, also known as gardenidone, is a chemical compound that belongs to the class of imidazolidines. It is a white to off-white crystalline powder with a molecular weight of 236.64 g/mol. 5-(4-chlorophenyl)imidazolidine-2,4-dione has various uses, including as an intermediate in the synthesis of pharmaceuticals and pesticides. It is also used as a reactant for the preparation of various organic compounds. Additionally, 5-(4-chlorophenyl)imidazolidine-2,4-dione has been studied for its potential pharmacological properties, including its antitumor and antifungal activities. However, it should be handled and used with caution, as it may pose certain health hazards and environmental risks.

Upstream product

• 124-38-9 carbon dioxide 
• 13312-83-9 4-chloromandelonitrile 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 170119-33-2 [1-(4-Chloro-phenyl)-2-pyrrolidin-1-yl-ethyl]-methyl-amine 
• 170119-37-6 (4-Chloro-phenyl)-methoxycarbonylamino-acetic acid 
• 170119-40-1 [1-(4-Chloro-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid methyl ester 
• 170119-35-4 Acetic acid {[1-(4-chloro-phenyl)-2-pyrrolidin-1-yl-ethyl]-methyl-carbamoyl}-(3,4-dichloro-phenyl)-methyl ester 
• 131402-92-1 Amino-(4-chloro-phenyl)-acetic acid hexyl ester; hydrochloride 
• 131402-93-2 Amino-(4-chloro-phenyl)-acetic acid heptyl ester; hydrochloride 
• 126746-12-1 DL-2-(p-Chlorphenyl)glycinoctylesterhydrochlorid 
• 92874-70-9 DL-Benzyloxycarbonylamino-<4-chlor-phenyl>-essigsaeure 

Relevant articles and documents

Method for continuously and quickly preparing DL-phenylglycine and analogue thereof

The invention provides a method for continuously and quickly preparing DL-phenylglycine and an analogue thereof. The method comprises the steps of adding 2-hydroxyl-phenylacetonitrile and an analoguethereof (cyanohydrin for short) and an aqueous ammonium bicarbonate solution into a microchannel reactor for a reaction, controlling the reaction temperature to be 80-130 DEG C, and controlling the reaction pressure to be 0.5-2.0 MPa, wherein the standing time of the reactants in a microchannel is 1-8 min, and an aqueous solution of 5-phenyl-hydantoin and an analogue thereof (hydantoin for short)is obtained; adding the hydantoin and alkali into the microchannel reactor for a reaction, controlling the reaction temperature to be 120-200 DEG C, and controlling the reaction pressure to be 1.0-3.5MPa, wherein the standing time of the reactants in the microchannel is 1-8 min, and then a saline solution of phenylglycine and an analogue thereof is obtained; conducting acidification neutralization and crystallization to obtain the phenylglycine and the analogue thereof. According to the method, the microchannel reactor is adopted, the reaction time is greatly shorted, the reaction speed is increased, pyrolysis and polymerization of the cyanohydrin are reduced, no by-products are generated, the products are high in yield, clean and environmentally friendly, and the production cost is lowered.

Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl-D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers.