1703-07-7

Basic information

• Product Name: 6-chloro-5-methyl-2H-pyridazin-3-one
• Synonyms: 6-chloro-5-methyl-2H-pyridazin-3-one;6-Chloro-5-Methylpyridazin-3(2H)-one;3(2H)-Pyridazinone, 6-chloro-5-Methyl-;6-Chloro-3-hydroxy-5-methylpyridazine;6-Chloro-5-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-5-methyl-1,2-diazine;3-chloro-4-methyl-1H-pyridazin-6-one
• CAS NO: 1703-07-7
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.56
• Mol File: 1703-07-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 225 °C(Solv: water (7732-18-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.45g/cm³
• Refractive Index: 1.608
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.83±0.60(Predicted)
• CAS DataBase Reference: 6-chloro-5-methyl-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-5-methyl-2H-pyridazin-3-one(1703-07-7)
• EPA Substance Registry System: 6-chloro-5-methyl-2H-pyridazin-3-one(1703-07-7)

Safety Data

• Hazardous Substances Data: 1703-07-7(Hazardous Substances Data)

Usage

General Description

6-chloro-5-methyl-2H-pyridazin-3-one, also known as ethiprole, is an insecticide and acaricide belonging to the chemical class of pyridine compounds. It is widely used in agriculture to control a variety of pests, including aphids, thrips, and mites, on a range of crops such as vegetables, fruits, and ornamentals. Ethiprole works by disrupting the nervous system of insects and mites, leading to paralysis and eventual death. It is considered to have low toxicity to mammals and non-target organisms, making it a popular choice for pest control in integrated pest management programs. However, ethiprole has been subject to regulatory restrictions and its use is limited in some regions due to potential environmental and human health concerns.

InChI:InChI=1/C5H5ClN2O/c1-3-2-4(9)7-8-5(3)6/h2H,1H3,(H,7,9)

Upstream product

• 19064-64-3 3,6-dichloro-4-methylpyridazine 
• 616-02-4 citraconic acid anhydride 
• 5754-18-7 4-methyl-1,2-dihydropyridazine-3,6-dione 
• 89466-36-4 3-chloro-6-methoxy-4-methylpyridazine 

Downstream Products

• 1194063-22-3 C₁₃H₁₂Cl₂N₂O₂ 
• 89283-31-8 3-chloro-5-methylpyridazine 
• 61404-48-6 3-chloro-6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid 
• 54709-94-3 5-methylpyridazin-3(2H)-one 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4, 5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic heteroaromatic replacement subunits for the pyrazolo[1,5-a]pyridine core of KCA-1490 has identified the 4-methoxy-2- (trifluoromethyl)benzo[d]thiazol-7-yl and 8-methoxy-2-(trifluoromethyl)quinolin- 5-yl analogues as dual PDE3/4-inhibitory compounds that potently suppress histamine-induced bronchoconstriction and exhibit anti-inflammatory activity in vivo.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.