1703-07-7

Basic information

• Product Name: 6-chloro-5-methyl-2H-pyridazin-3-one
• Synonyms: 6-chloro-5-methyl-2H-pyridazin-3-one;6-Chloro-5-Methylpyridazin-3(2H)-one;3(2H)-Pyridazinone, 6-chloro-5-Methyl-;6-Chloro-3-hydroxy-5-methylpyridazine;6-Chloro-5-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-5-methyl-1,2-diazine;3-chloro-4-methyl-1H-pyridazin-6-one
• CAS NO: 1703-07-7
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.56
• Mol File: 1703-07-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 225 °C(Solv: water (7732-18-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.45g/cm³
• Refractive Index: 1.608
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.83±0.60(Predicted)
• CAS DataBase Reference: 6-chloro-5-methyl-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-5-methyl-2H-pyridazin-3-one(1703-07-7)
• EPA Substance Registry System: 6-chloro-5-methyl-2H-pyridazin-3-one(1703-07-7)

Safety Data

• Hazardous Substances Data: 1703-07-7(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Pest Control:
6-chloro-5-methyl-2H-pyridazin-3-one is used as an insecticide and acaricide for controlling pests such as aphids, thrips, and mites on various crops. It is applied for its effectiveness in disrupting the nervous systems of these pests, leading to their paralysis and death, thereby protecting crops from damage and increasing yield.
Used in Integrated Pest Management Programs:
In integrated pest management, 6-chloro-5-methyl-2H-pyridazin-3-one is used as a key component due to its low toxicity to mammals and non-target organisms. It helps in reducing the reliance on more harmful chemical pesticides, promoting a more sustainable and environmentally friendly approach to pest control.

InChI:InChI=1/C5H5ClN2O/c1-3-2-4(9)7-8-5(3)6/h2H,1H3,(H,7,9)

Upstream product

• 89466-36-4 3-chloro-6-methoxy-4-methylpyridazine 
• 616-02-4 citraconic acid anhydride 
• 5754-18-7 4-methyl-1,2-dihydropyridazine-3,6-dione 
• 19064-64-3 3,6-dichloro-4-methylpyridazine 

Downstream Products

• 1194063-22-3 C₁₃H₁₂Cl₂N₂O₂ 
• 89283-31-8 3-chloro-5-methylpyridazine 
• 61404-48-6 3-chloro-6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid 
• 54709-94-3 5-methylpyridazin-3(2H)-one 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4, 5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic heteroaromatic replacement subunits for the pyrazolo[1,5-a]pyridine core of KCA-1490 has identified the 4-methoxy-2- (trifluoromethyl)benzo[d]thiazol-7-yl and 8-methoxy-2-(trifluoromethyl)quinolin- 5-yl analogues as dual PDE3/4-inhibitory compounds that potently suppress histamine-induced bronchoconstriction and exhibit anti-inflammatory activity in vivo.

INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the Formula (I), (Ia1-10), (Ib1-10), (Ic1-10), (Id1-7), (Ie1-5) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.

Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient

Novel pyrazolopyridine-4-yl pyridazinone derivatives serve as phosphodiesterase inhibitors and are useful compounds for use in pharmaceutical products. Specifically, the compounds of the present invention are pyrazolopyridine-4-yl pyridazinone derivatives represented by the following general formula (1): (Example: 6-(2-ethyl-7-methoxy-pyrazolo[1,5-a]pyridine-4-yl)-5-methyl-4, 5-dihydro-3(2H)-pyridazinone).