54709-94-3

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Methyl-3(2H)-pyridazinone is utilized as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of drugs for a range of medical conditions. Its unique structure allows for the creation of diverse medicinal compounds with potential therapeutic applications.
Used in Organic Chemistry:
As a heterocyclic compound, 5-Methyl-3(2H)-pyridazinone serves as a valuable starting material in organic chemistry, facilitating the production of other complex organic molecules. Its reactivity and functional groups make it suitable for a variety of chemical reactions and transformations.
Used in Drug Development:
5-Methyl-3(2H)-pyridazinone has been studied for its potential pharmacological properties, indicating its use in the development of new drugs. Its presence in various chemical structures may contribute to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Chemical Production:
5-Methyl-3(2H)-pyridazinone may also be employed as an intermediate in the production of other chemicals, highlighting its importance in the chemical industry. Its versatility and reactivity make it a useful component in the synthesis of a wide array of chemical products.

InChI:InChI=1/C5H6N2O/c1-4-2-5(8)7-6-3-4/h2-3H,1H3,(H,7,8)

Upstream product

• 83803-81-0 ethyl (E/Z)-4,4-dimethoxy-3-methylbut-2-enoate 
• 19064-64-3 3,6-dichloro-4-methylpyridazine 
• 89466-36-4 3-chloro-6-methoxy-4-methylpyridazine 
• 1173165-21-3 N'-acryloyl-4-methyl-N-(2-methylallyl)benzenesulfonohydrazide 
• 78920-07-7 γ-morpholinobutenolide 
• 40834-42-2 5-hydroxy-4-methyl-5H-furan-2-one 
• 83297-15-8 5-(1,2-diaza-1-t-butyl-4-methylbutadien-4-ylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 78920-13-5 2-ethoxy-3-methyl-2H-furan-5-one 
• 342402-51-1 5-methyl-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid 
• 1703-07-7 6-chloro-5-methyl-2H-pyridazin-3-one 

Downstream Products

• 1120-88-3 4-methylpyridazine 
• 89283-31-8 3-chloro-5-methylpyridazine 

Relevant academic research and scientific papers

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system. The Royal Society of Chemistry 2009.

FUSED PYRROLIDINE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

1,2,3-TRIAZOLE PYRROLIDINE DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

THIOPHENE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalisation of the metathesis products is possible both prior to and after aromatisation. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds.

MGLUR5 MODULATORS

The present invention is directed to compounds of formula (I) Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in

MGluR5 modulators I

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

MGluR5 modulators V

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

The Reaction of Meldrum's Acid with α-Dicarbonyl Monohydrazones: A New Synthesis of Pyridazin-3-ones

Treatment of the monohydrazones of α-dicarbonyl compounds with Meldrum's acid gives the condensation products (13)-(19) under standard conditions.Reaction of pyruvaldehyde 2-phenylhydrazone or 2-t-butylhydrazone with Meldrum's acid at 80 deg C gives the corresponding 2-substituted-2,3-dihydro-6-methyl-3-oxo-pyridazine-4-carboxylic acids (29) and (30).Cyclisation of the other N-monosubstituted condensation products (13), (14), (16), (18), and (19) to 3-oxopyridazine-4-carboxylic acids (31)-(35) can be effected under basic conditions.Gas-phase pyrolysis of the N-aryl derivatives (13)-(16) at 550 deg C and 10E-2 Torr gives N-arylpyridazin-3-ones (38)-(41) while the N-t-butyl derivatives (18) and (19) at 750 deg C and 10E-2 Torr give N-unsubstituted pyridazin-3-ones (44) and (45) by additional loss of 2-methylpropene. 2-t-Butylpyridazin-3-ones (42) and (43) can be isolated from the same precursors under milder conditions (500 deg C and 10E-2 Torr).Pyrolysis of the N,N-dimethyl derivative (17) gave only polymeric material.