170377-12-5

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 78-94-4 methyl vinyl ketone 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1330174-12-3 ethyl 2-methylene-3-oxo-1-p-tolylbutyl(tosyl)carbamate 
• 1308285-82-6 (S)-4-isorpopyl-4-((R)-2-methylene-3-oxo-1-p-tolylbutyl)-2-phenyloxazol-5(4H)-one 
• 1308285-90-6 (S)-4-methyl-4-((R)-2-methylene-3-oxo-1-p-tolylbutyl)-2-phenyloxazol-5(4H)-one 
• 1304688-64-9 tert-butyl (2-methylene-3-oxo-1-(p-tolyl)butyl) carbonate 
• 232944-73-9 (3Z)-3-(chloromethyl)-4-(4-methylphenyl)but-3-en-2-one 

Relevant academic research and scientific papers

A Porous Cu(II)-MOF with Proline Embellished Cavity: Cooperative Catalysis for the Baylis-Hillman Reaction

l-Proline has been covalently attached in a rigid linear ligand, H4L, having an isophthalate moiety at each terminal to form the chiral ligand, H4LPRO. This linker has been used for the construction of a porous MOF, LCuPRO

L-proline and L-histidine co-catalyzed Baylis-Hillman reaction

Baylis-Hillman reaction between an aldehyde and an activated alkene, such as alkyl vinyl ketones, acrylates, acrylonitrile, and vinylsulfones, giving the β-hydroxy-α-methylene carbonyl compounds, is a versatile and atom-economical carbon-carbon bond-formi

Brucine N-oxide-catalyzed Morita-Baylis-Hillman reaction of vinyl ketones: A mechanistic implication of dual catalyst system with proline

The brucine N-oxide promoted Morita-Baylis-Hillman (MBH) reaction of vinyl ketones with aldehydes has been achieved. The corresponding asymmetric version of MBH reaction was also investigated, and the electron-deficient aryl aldehydes have emerged as suit

First evidence of proline acting as a bifunctional catalyst in the Baylis-Hillman reaction between alkyl vinyl ketones and aryl aldehydes

Proline in the presence of sodium hydrogen carbonate has been found to be an effective catalyst for the Baylis-Hillman reaction between methyl or ethyl vinyl ketone and aryl aldehydes. Screening of several amine catalysts showed that an ionizable carboxyl

A highly active ionic liquid catalyst for Morita-Baylis-Hillman reaction

The Morita-Baylis-Hillman reaction is an efficient carbon-carbon bond forming reaction for the preparation of α-methylene-β-hydroxycarbonyl compounds. A new and highly active di-naphthalene imidazolium salt has been synthesized. We have found that 1,3-bis

Traditional Morita-Baylis-Hillman reaction of aldehydes with methyl vinyl ketone co-catalyzed by triphenylphosphine and nitrophenol

The development of a chiral Broonsted acid-catalyzed asymmetric Morita-Baylis-Hilman reaction of cyclone with aldehyde in the presence of triethyphosphine (PE3) was analyzed using nuclear magnetic resonance (NMR). Another catalytic system for t

Polymer-Supported Lewis Bases for the Baylis-Hillman Reaction

The use of polymer-supported Lewis bases such as PEG4600- (PPh2)2 and poly(DMAP) in the Baylis-Hillman reactions of N-tosylimines (ArCH=NTs) 1 or the corresponding arenecarbaldehydes with α,β-unsaturated ketones has been i

Stereoselective transformation of Baylis-Hillman adducts into (3E)-3- (alkoxymethyl)alk-3-en-2-ones

The pure (3E)-3-(methoxymethyl)alk-3-en-2-ones and (3E)-3- (ethoxymethyl)alk-3-en-2-ones are formed in the acid induced reaction of 4- hydroxy-3-methylenealkan-2-ones with methanol and ethanol, respectively.

Synthetic applications of the Baylis-Hillman adducts: A simple stereoselective synthesis of (E)-3-(nitroxymethyl)alk-3-en-2-ones

First simple, stereoselective synthesis of (E)-3-(nitroxymethyl)alk-3-en-2-ones from Baylis-Hillman adducts (4-hydroxy-3-methylenealkan-2-ones) is described. (C) 2000 Elsevier Science Ltd.

2,6-diphenyl-4H-chalcogenopyran-4-ones and 2,6-diphenyl-4H- chalcogenopyran-4-thiones: A new catalyst for the Baylis-Hillman reaction

2,6-Diphenyl-4H-chalcogenopyran-4-ones and 2,6-diphenyl-4H- chalcogenopyran-4-thiones, a new series of catalysts for the Baylis-Hillman reaction, were investigated. The reactions proceeded smoothly in the presence of 1 mol eq. of TiCl4 under at