17039-14-4 Usage
Structure
Contains a pyrimidine ring with a chlorophenyl group and two amino groups at the 2 and 4 positions
Uses
Building block in the synthesis of pharmaceuticals and agrochemicals, kinase inhibitor with potential anti-cancer and anti-inflammatory properties, research tool in studying protein kinases and cellular processes
Importance
Important intermediate in the synthesis of biologically active molecules and significant role in medicinal and chemical research
Check Digit Verification of cas no
The CAS Registry Mumber 17039-14-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,3 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17039-14:
(7*1)+(6*7)+(5*0)+(4*3)+(3*9)+(2*1)+(1*4)=94
94 % 10 = 4
So 17039-14-4 is a valid CAS Registry Number.
17039-14-4Relevant articles and documents
Mechanochemical Magnesium-Mediated Minisci C-H Alkylation of Pyrimidines with Alkyl Bromides and Chlorides
Wu, Chongyang,Ying, Tao,Yang, Xinjie,Su, Weike,Dushkin, Alexandr V.,Yu, Jingbo
, p. 6423 - 6428 (2021)
A novel method to synthesize 4-alkylpyrimidines by the mechanochemical magnesium-mediated Minisci reaction of pyrimidine derivatives and alkyl halides has been reported. The reaction process operates with a broad substrate scope and excellent regioselectivity under mild conditions with no requirement of transition-metal catalysts, solvents, and inert gas protection. The practicality of this protocol has been demonstrated by the up-scale synthesis, mechanochemical product derivatization, and antimalarial drug pyrimethamine preparation.
