170439-72-2

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 102000-72-6 3-vinylpyridin-2-amine 

Downstream Products

• 129803-99-2 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 
• 176314-34-4 C₂₂H₁₇N₅OS 

Relevant academic research and scientific papers

Hydrogen-Transfer-Mediated α-Functionalization of 1,8-Naphthyridines by a Strategy Overcoming the Over-Hydrogenation Barrier

A general catalytic hydrogen transfer-mediated α-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a hydrogen transfer-mediated activation mode for non-activated pyridyl cores. The pyridyl α-site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel α-functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemoselectivity issue. The developed chemistry features operational simplicity, readily available catalyst and good functional group tolerance, and offers a significant basis for further development of new protocols to directly transform or functionalize inert N-heterocycles.

Indium(Iii) Chloride as an efficient catalyst for friedlander synthesis 1,8-Naphthyridines under solventfree conditions

InCl3 catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3 in high yields. The method is simple an

INHIBITORS OF TRKA KINASE

The present invention is directed to the compounds of Formula I which are inhibitors of tropomyosin-related kinase A (TrkA): Formula (I) or steroisomers, tautomers or a pharmaceutically acceptable salts, metabolites, isotopes, solvates or prodrugs thereof

Cecl3.7H2O catalyzed Friedlander synthesis of 1,8-naphthyridines under solvent-free grinding conditions

CeCl3.7H2O catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with varius carbonyl compounds containing α-methylene group 2 in solvent-free grinding conditions to afford the corresponding 1,8-naphthyridines 3. The rea

ZrOClinf2/inf.8Hinf2/infO catalyzed solvent-free Friedlander synthesis of 1,8-naphthyridines

ZrOClinf2/inf.8Hinf2/infO catalyzed Friedlander condensation of 2-Aminonicotinaldehyde 1 with carbonyl compounds containing-methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3. The yields are very good and

Green approach for the efficient synthesis of 1,8-naphthyridines promoted by citric acid

Citric acid catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α-methylene group 2 has been achieved under neat conditions at 100° to give the corresponding 1,8-naphthyridines 3. The products are obta

A simple and efficient protocol for the synthesis of 1,8- naphthyridines using sodium hydrogensulfate on silica gel under solvent free condition

A simple and efficient method for the synthesis of 1,8-naphthyridines using silicagel supported sodium hydrogen sulfate as reusable eco-friendly catalyst via Friedlander annulation under solvent-free conditions is described. A series of functionalized der

Potassium triiodide catalyzed Friedlander synthesis of 1,8-naphthyridines in aqueous media

Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in aqueous media to afford 1,-naphthyridines 3 in high yields.

Microwave-assisted solvent-free Friedlander synthesis of 1,8-naphthyridines using ammonium acetate as catalyst

The microwave enhanced synthesis of 1,8-naphthyridines 3 is achieved rapidly and in good yield via the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in the presence of ammonium acetate.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to nitrogen-containing compounds according to formula (I) and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ? cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.